Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Sciences.
Jpn J Infect Dis. 2013;66(5):446-8. doi: 10.7883/yoken.66.446.
Diarrheagenic Escherichia coli (DEC) is a major etiologic agent of childhood diarrhea in developing countries. We investigated the frequency of DEC in stool samples from 125 diarrheal children (age, 1-10 years) and 92 non-diarrheal children in Surabaya, Indonesia. The non-diarrheal children served as healthy controls. DEC was detected in 23 of 125 (18.4%) and 47 of 92 (51.1%) samples in the diarrheal and non-diarrheal children, respectively. Enteropathogenic E. coli was the most prevalent in the non-diarrheal children (25.0%), and its prevalence was significantly higher than that in the diarrheal children (0.8%) (P < 0.0001). Interestingly, Shiga toxin-producing E. coli (4.3%) was detected only in the non-diarrheal children (P = 0.031). This is the first study comparing between diarrheal children with non-diarrheal or healthy children to investigate the role of DEC in pediatric diarrheal diseases in Indonesia.
产毒性大肠杆菌（DEC）是发展中国家儿童腹泻的主要病原体。我们调查了印度尼西亚泗水 125 名腹泻儿童（年龄 1-10 岁）和 92 名非腹泻儿童粪便样本中 DEC 的频率。非腹泻儿童作为健康对照。在腹泻和非腹泻儿童的样本中，分别检测到 23 例（18.4%）和 47 例（51.1%）存在 DEC。肠致病性大肠杆菌在非腹泻儿童中最为常见（25.0%），其患病率明显高于腹泻儿童（0.8%）（P<0.0001）。有趣的是，仅在非腹泻儿童中检测到产志贺毒素大肠杆菌（4.3%）（P=0.031）。这是第一项比较腹泻儿童与非腹泻或健康儿童以调查 DEC 在印度尼西亚儿童腹泻病中的作用的研究。
