Tanno Sachie, Onodera Hideki, Inoue Syoichi, Honda Ryoichi, Nagashima Kazuo, Ohsaki Yoshinobu
Dept. of Respiratory Medicine, Sapporo Higashi Tokushukai Hospital, Japan.
Gan To Kagaku Ryoho. 2013 Sep;40(9):1205-8.
Large cell neuroendocrine carcinoma(LCNEC)is a rare malignant disease with a poor and the clinical outcome. Although no standard chemotherapy regimen has been developed, LCNEC should be treated in a manner similar to that used for small cell lung cancer because of their similar chemosensitivity and aggressive characteristics, even though LCNEC is classified as non-small cell lung cancer. A 78-year-old man was admitted with the complaint of convulsions on the left side of his body. A chest computed tomographic(CT)scan on admission demonstrated a 4 cm mass in a left lung S9. Brain magnetic resonance imaging(MRI)revealed enhanced tumors in the left occipital lobe. The brain tumor was surgically resected and histological findings were diagnosed as LCNEC. After induction of 4 courses with irinotecan and split-dose cisplatin chemotherapy, a partial response was obtained. After 4 courses, the tumor size was increased, and the chemotherapy was changed to amrubicin. The patient is alive and with no relapse.
大细胞神经内分泌癌（LCNEC）是一种罕见的恶性疾病，临床预后较差。尽管尚未制定出标准的化疗方案，但由于LCNEC与小细胞肺癌具有相似的化疗敏感性和侵袭性特征，即使LCNEC被归类为非小细胞肺癌，其治疗方式也应与小细胞肺癌相似。一名78岁男性因左侧身体抽搐主诉入院。入院时胸部计算机断层扫描（CT）显示左肺S9区有一个4厘米的肿块。脑部磁共振成像（MRI）显示左枕叶有强化肿瘤。脑部肿瘤经手术切除，组织学检查结果诊断为LCNEC。在接受4个疗程的伊立替康和分剂量顺铂化疗诱导后，获得了部分缓解。4个疗程后，肿瘤大小增大，化疗改为氨柔比星。患者存活且无复发。
