Haga Takahiro, Nakajima Yuki, Kitamura Atsushi, Kuroda Fuminobu, Takiguchi Yuichi, Tatsumi Koichiro
Department of Respirology, Graduate School of Medicine, Chiba University.
Nihon Kokyuki Gakkai Zasshi. 2010 Oct;48(10):755-8.
A 46-year-old man presented with chest pain at a local hospital in July 2007. Chest computed tomography (CT) showed a 48-mm mass in the anterior mediastinum. CT-guided percutaneous tumor biopsy demonstrated large cell neuroendocrine carcinoma of the thymus. He was referred to our hospital in August 2007. Because the tumor had already progressed to stage IVb according to the Masaoka classification of thymic epithelial tumors, the patient was treated with combination chemotherapy of cisplatin and irinotecan, which achieved a partial response. However, the tumor relapsed in February 2008. He died, despite 2 separate cycles of chemotherapy with docetaxel only and amrubicin only in August 2008. We encountered a rare case of large cell neuroendocrine carcinoma of the thymus treated with combination chemotherapy of cisplatin and irinotecan.
一名46岁男性于2007年7月在当地医院因胸痛就诊。胸部计算机断层扫描（CT）显示前纵隔有一个48毫米的肿块。CT引导下经皮肿瘤活检显示为胸腺大细胞神经内分泌癌。他于2007年8月转诊至我院。根据胸腺瘤的Masaoka分类，由于肿瘤已进展至IVb期，该患者接受了顺铂和伊立替康联合化疗，取得了部分缓解。然而，肿瘤于2008年2月复发。尽管在2008年8月分别进行了仅使用多西他赛和仅使用氨柔比星的两个化疗周期，但他仍死亡。我们遇到了一例罕见的胸腺大细胞神经内分泌癌患者，接受了顺铂和伊立替康联合化疗。
