Nemoto Hiroko, Sato Tsutomu, Rino Yasushi, Uchiyama Mamoru, Atsumi Yosuke, Hasegawa Shinichi, Tamagawa Hiroshi, Oshima Takashi, Yukawa Norio, Yoshikawa Takaki, Imada Toshio, Masuda Munetaka
Dept. of Surgery, Yokohama City Unversity, Japan.
Gan To Kagaku Ryoho. 2013 Sep;40(9):1221-4.
We report a curative resection of a case with advanced gastric cancer responding remarkably well to combination chemotherapy of docetaxel, cisplatin and S-1. The patient was a 71-year-old man with gastric cancer of Borrmann type 3 accompanied with N3. Staging laparoscopy revealed peritoneal dissemination. He was administered docetaxel intravenously at 40mg/ m2 on day 1, cisplatin intravenously at 60 mg/m2 on day 1, and S-1 orally at 80 mg/m2 on days 1 to 14. This treatment was repeated every 28 days as one course. According to gastroscope and CT findings, a significant tumor reduction was obtained after 4 courses. After 6 courses, a CT scan revealed partial response of the lymph node metastasis, and the serum CEA value was normalized. Curative total gastrectomy was performed. The histological effect of the primary lesion was judged to be grade 2. Combination chemotherapy of S-1, cisplatin and docetaxel can be effective and feasible for advanced gastric cancer.
我们报告了一例晚期胃癌患者经多西他赛、顺铂和S-1联合化疗后实现根治性切除且反应良好的病例。该患者为一名71岁男性，患有Borrmann 3型胃癌并伴有N3。分期腹腔镜检查发现腹膜播散。患者在第1天静脉注射多西他赛40mg/m²，第1天静脉注射顺铂60mg/m²，第1至14天口服S-1 80mg/m²。每28天重复此治疗作为一个疗程。根据胃镜和CT检查结果，4个疗程后肿瘤显著缩小。6个疗程后，CT扫描显示淋巴结转移部分缓解，血清CEA值恢复正常。进行了根治性全胃切除术。原发灶的组织学疗效判定为2级。S-1、顺铂和多西他赛联合化疗对晚期胃癌可能有效且可行。
