de Jesus M, Tang W, Sadjadi M, Belmonte A H, Poon T P
Department of Pathology, New York Medical College-Metropolitan Hospital Center, New York 10029.
Gynecol Oncol. 1990 Feb;36(2):263-70. doi: 10.1016/0090-8258(90)90185-n.
Verrucous carcinoma is a rare variant of epidermoid carcinoma with distinct clinical and histopathologic features. To date, 31 cases have been reported in the cervix. They are typically slow-growing, locally invasive tumors with low potential for lymphatic metastasis and appear to be radioresistant. We report a case which is unusual in having endometrial and deep myometrial invasion. Electron microscopy, immunohistochemical stains, and DNA in situ hybridization studies failed to detect human papilloma virus particles but the oncogenic potential of the virus is not excluded.
疣状癌是一种罕见的表皮样癌变体，具有独特的临床和组织病理学特征。迄今为止，宫颈部位已报道31例。它们通常生长缓慢，为局部浸润性肿瘤，淋巴转移潜能低，且似乎对放疗耐药。我们报告一例不寻常的病例，其存在子宫内膜和子宫肌层深部浸润。电子显微镜检查、免疫组织化学染色及DNA原位杂交研究均未检测到人乳头瘤病毒颗粒，但不排除该病毒的致癌潜能。
