Hammar S P, Insalaco S J, Lee R B, Bockus D E, Remington F L, Yu A
Diagnostic Specialties Laboratory, Bremerton, Washington 98310.
Am J Clin Pathol. 1992 Apr;97(4):516-22. doi: 10.1093/ajcp/97.4.516.
A case of amphicrine carcinoma of the uterine cervix is described in a 27-year-old woman whose initial cervical biopsy specimen showed small cell undifferentiated neuroendocrine carcinoma. Despite an initial complete clinical response to VP-16 and carboplatin, residual tumor was noted in the cervical cone biopsy specimen and she was treated with external-beam irradiation and cesium implants. The neoplasm subsequently metastasized and required additional VP-16 and carboplatin for control. The pathologic features and biologic behavior of this unusual type of neuroendocrine neoplasm are described in this case report.
本文报道了一例27岁子宫颈两性癌患者，其最初的宫颈活检标本显示为小细胞未分化神经内分泌癌。尽管最初对VP-16和顺铂治疗有完全的临床反应，但宫颈锥切活检标本中仍发现残留肿瘤，遂对其进行了外照射和铯植入治疗。肿瘤随后发生转移，需要额外的VP-16和顺铂来控制病情。本病例报告描述了这种不寻常类型神经内分泌肿瘤的病理特征和生物学行为。
