Katsuda Shin-ichiro, Miyashita Hiroshi, Shimada Kazuyuki, Miyawaki Yoshinori, Kojima Iwao, Shiogai Yuri, Hazama Akihiro
Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Jichi Medical University Health Care Center, Tochigi, Japan.
Hypertens Res. 2014 Jan;37(1):19-25. doi: 10.1038/hr.2013.104. Epub 2013 Sep 19.
We investigated whether the subservient relationship of peripheral to central hemodynamic parameters, such as the augmentation index (AI) and the second systolic (SBP2) and pulse pressures, were preserved with the progression of atherosclerosis in the Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbit, an animal model for hypercholesterolemia and atherosclerosis. Male KHC rabbits, aged 12 and 24 months, were anesthetized with pentobarbital sodium. Two catheter-tip transducers were introduced to the central (ascending aorta) and peripheral (distal region of the right brachial artery) arteries through the left common carotid and the right radial arteries, respectively. Pressure waves were simultaneously recorded under regular atrial pacing to investigate changes in response to the intravenous infusion of angiotensin II (Ang II) (30-40 ng kg(-1) min(-1)) and sodium nitroprusside (NTP) (20-30 μg kg(-1) min(-1)). Central systolic blood pressure (cSBP) and diastolic blood pressure (DBP), peripheral systolic blood pressure (pSBP) and DBP, and peripheral second systolic blood pressure (pSBP2) showed no significant difference between the 12- and 24-month-old groups before the administration of vasoactive drugs. There was no significant difference in central AI (cAI) between the two age groups before the drug infusion, even though atherosclerosis progressed with aging. Peripheral AI (pAI) changed in parallel with cAI in response to vasopressor and depressor actions due to the infusion of Ang II and NTP, respectively. We conclude that the subservience of pSBP2 to cSBP and pAI to cAI, in addition to the regression relationship of these parameters between peripheral and central arteries, were well preserved, irrespective of the progression of atherosclerosis.
我们研究了在黑泽和草柳高胆固醇血症（KHC）兔（一种高胆固醇血症和动脉粥样硬化动物模型）中，随着动脉粥样硬化的进展，外周血流动力学参数对中心血流动力学参数的从属关系，如增强指数（AI）、第二收缩压（SBP2）和脉压是否得以保留。12个月和24个月大的雄性KHC兔用戊巴比妥钠麻醉。通过左颈总动脉和右桡动脉分别将两个导管尖端换能器插入中心动脉（升主动脉）和外周动脉（右肱动脉远端区域）。在常规心房起搏下同时记录压力波，以研究静脉输注血管紧张素II（Ang II）（30 - 40 ng kg⁻¹ min⁻¹）和硝普钠（NTP）（20 - 30 μg kg⁻¹ min⁻¹）时的反应变化。在给予血管活性药物之前，12个月龄组和24个月龄组的中心收缩压（cSBP）、舒张压（DBP）、外周收缩压（pSBP）、DBP以及外周第二收缩压（pSBP2）均无显著差异。在药物输注前，尽管动脉粥样硬化随年龄进展，但两个年龄组的中心AI（cAI）并无显著差异。由于分别输注Ang II和NTP导致的升压和降压作用，外周AI（pAI）与cAI平行变化。我们得出结论，无论动脉粥样硬化的进展如何，pSBP2对cSBP以及pAI对cAI的从属关系，以及这些参数在外周动脉和中心动脉之间的回归关系均得到了很好的保留。
