Katsuda Shin-Ichiro, Yasukawa Takeshi, Nakagawa Koji, Miyake Masao, Yamasaki Masao, Katahira Kiyoaki, Mohri Motohiko, Shimizu Tsuyoshi, Hazama Akihiro
Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Biol Pharm Bull. 2008 Jan;31(1):38-44. doi: 10.1248/bpb.31.38.
Deep-sea water is rich in minerals, e.g., Mg, Ca, and K which have been considered to be associated with prevention of cardiovascular disease. We investigated the effect of deep-sea water on cardiovascular hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) rabbits. Deep-sea water was pumped in the offing of Cape Muroto in Japan and the mineral constituents were refined to a degree of hardness of 1,000. Twenty four 4-month-old KHC rabbits were given refined deep-sea water (n=12) and tap water (n=12) for 6 months. Pressure and flow waves at the ascending aorta were recorded under pentobarbital anesthesia. Systolic, diastolic, pulse and mean arterial pressures and total peripheral resistance were significantly lower in the deep-sea water group than in the control group. There were no significant differences in changes in serum lipid levels, plasma renin and angiotensin converting enzyme activities and electrolyte levels except for Mg(2+) after the feeding of the water between the two groups. A slight increase in serum Mg(2+) level in the deep-sea water group may not account for the inhibition of mild hypertension. From our results, we conclude that deep-sea water could improve cardiovascular hemodynamics, even though the factors which affect the blood pressure are still unknown.
深海水中富含矿物质，例如镁、钙和钾，这些矿物质被认为与预防心血管疾病有关。我们研究了深海水对黑泽和草柳高胆固醇血症（KHC）兔心血管血液动力学的影响。从日本室户岬近海抽取深海海水，并将其矿物质成分精炼至硬度为1000的程度。给24只4个月大的KHC兔分别饮用精炼深海海水（n = 12）和自来水（n = 12），持续6个月。在戊巴比妥麻醉下记录升主动脉处的压力和血流波形。深海海水组的收缩压、舒张压、脉压和平均动脉压以及总外周阻力均显著低于对照组。两组在饮水后，除镁离子外，血清脂质水平、血浆肾素和血管紧张素转换酶活性以及电解质水平的变化均无显著差异。深海海水组血清镁离子水平的轻微升高可能无法解释其对轻度高血压的抑制作用。根据我们的研究结果，我们得出结论，尽管影响血压的因素尚不清楚，但深海水可以改善心血管血液动力学。
