Downie J W, Dean D M, Carro-Ciampi G, Awad S A
Can J Physiol Pharmacol. 1975 Aug;53(4):525-30. doi: 10.1139/y75-074.
In cumulative dose-response studies, strips from bladder neck of rabbit were significantly more sensitive to stimulation with noradrenaline, phenylephrine, and methoxamine than were strips from detrusor. There was no difference between the two regions in sensitivity to isoprenaline or carbachol. From the known characteristics of these agents, it seemed unlikely that metabolic destruction or uptake could account for the different sensitivities seen. Also, neither normetanephrine nor desmethylimipramine could alter significantly the potency of noradrenaline in either area of the bladder. It seems likely that the difference in sensitivity to alpha-adrenoceptor stimulation in the bladder neck and detrusor is due to factors at the receptor level.
在累积剂量-反应研究中，兔膀胱颈的组织条对去甲肾上腺素、去氧肾上腺素和甲氧明刺激的敏感性明显高于逼尿肌组织条。在对异丙肾上腺素或卡巴胆碱的敏感性方面，这两个区域没有差异。从这些药物的已知特性来看，代谢破坏或摄取似乎不太可能解释所观察到的不同敏感性。此外，去甲变肾上腺素和去甲基丙咪嗪均不能显著改变膀胱任一区域中去甲肾上腺素的效力。膀胱颈和逼尿肌对α-肾上腺素能受体刺激的敏感性差异似乎是由于受体水平的因素所致。
