α-和β-肾上腺素能受体在人膀胱中的分布
Distribution of alpha- and beta-adrenoceptors in human urinary bladder.
作者信息
Awad S A, Bruce A W, Carro-Ciampi G, Downie J W, Lin M, Marks G S
出版信息
Br J Pharmacol. 1974 Apr;50(4):525-9. doi: 10.1111/j.1476-5381.1974.tb08585.x.
Abstract
1 The distribution of alpha- and beta-adrenoceptors in isolated preparations of human bladder neck and detrusor muscle has been studied.2 Adrenaline caused contraction of the bladder neck which was blocked by phenoxybenzamine but unaltered by propranolol.3 Isoprenaline caused relaxation of the bladder neck which was blocked by propranolol. High concentrations caused contraction which was enhanced by propranolol but blocked by phenoxybenzamine.4 Detrusor muscle was relaxed by isoprenaline and this effect was blocked by propranolol. Phenylephrine caused relaxation of detrusor which was unaffected by phenoxybenzamine; in some cases contraction was produced in the presence of propranolol.5 It is concluded that the bladder neck contains mainly alpha-receptors and the detrusor mainly beta-receptors but both regions posses both types of adrenoceptor.
摘要
对人膀胱颈和逼尿肌的离体标本中α-和β-肾上腺素能受体的分布进行了研究。
肾上腺素引起膀胱颈收缩，此收缩被酚苄明阻断，但不受普萘洛尔影响。
异丙肾上腺素引起膀胱颈松弛，此松弛被普萘洛尔阻断。高浓度时引起收缩，此收缩被普萘洛尔增强，但被酚苄明阻断。
逼尿肌被异丙肾上腺素松弛，此效应被普萘洛尔阻断。去氧肾上腺素引起逼尿肌松弛，此松弛不受酚苄明影响；在某些情况下，在普萘洛尔存在时可产生收缩。
得出结论：膀胱颈主要含有α受体，逼尿肌主要含有β受体，但两个区域均存在两种类型的肾上腺素能受体。
相似文献
1
Distribution of alpha- and beta-adrenoceptors in human urinary bladder.α-和β-肾上腺素能受体在人膀胱中的分布
Br J Pharmacol. 1974 Apr;50(4):525-9. doi: 10.1111/j.1476-5381.1974.tb08585.x.
2
Urinary bladder contractility: action of imipramine.膀胱收缩性：丙咪嗪的作用
Arch Phys Med Rehabil. 1974 Apr;55(4):166-70.
3
Autonomic receptors in smooth muscle of cat urinary bladder.猫膀胱平滑肌中的自主受体。
Gen Pharmacol. 1981;12(1):37-40. doi: 10.1016/0306-3623(81)90025-2.
4
alpha And beta-adrenoceptors in the detrusor muscle and bladder base of the pig and beta-adrenoceptors in the detrusor muscle of man.猪逼尿肌和膀胱底部的α和β肾上腺素能受体以及人逼尿肌中的β肾上腺素能受体。
Br J Pharmacol. 1979 Feb;65(2):215-22. doi: 10.1111/j.1476-5381.1979.tb07821.x.
5
Alpha- and beta-adrenoceptors in the sheep urinary bladder.
Res Vet Sci. 1991 May;50(3):259-63. doi: 10.1016/0034-5288(91)90120-d.
6
Distribution and types of adrenoceptors in the guinea-pig ileum: the action of alpha- and beta-adrenoceptor blocking agents.豚鼠回肠中肾上腺素能受体的分布及类型：α和β肾上腺素能受体阻断剂的作用
Br J Pharmacol. 1982 Aug;76(4):569-78. doi: 10.1111/j.1476-5381.1982.tb09256.x.
7
The effect of isoprenaline on adrenoceptors in human saphenous vein.异丙肾上腺素对人隐静脉肾上腺素能受体的作用。
Br J Pharmacol. 1970 Jul;39(3):465-75. doi: 10.1111/j.1476-5381.1970.tb10355.x.
8
Evidences for alpha excitatory action of catecholamines on the electrical activity of the guinea-pig stomach.儿茶酚胺对豚鼠胃电活动的α兴奋作用的证据。
Jpn J Physiol. 1976;26(1):41-52. doi: 10.2170/jjphysiol.26.41.
9
Adrenergic reactions of sheep rumen in vitro.绵羊瘤胃体外肾上腺素能反应
Acta Physiol Pol. 1980 Jul-Aug;31(4):341-8.
10
Further study of the adrenoceptors of the saphenous vein of the dog: influence of factors which interfere with the concentrations of agonists at the receptor level.犬隐静脉肾上腺素能受体的进一步研究：受体水平上影响激动剂浓度的因素的作用
Eur J Pharmacol. 1975 Nov;34(1):9-19. doi: 10.1016/0014-2999(75)90220-4.
引用本文的文献
1
Urinary Retention Following Methamphetamine and Cannabis Abuse in a 33-Year-Old Male.一名33岁男性滥用甲基苯丙胺和大麻后出现尿潴留
Cureus. 2024 Mar 27;16(3):e57033. doi: 10.7759/cureus.57033. eCollection 2024 Mar.
2
Capsaicin-Sensitive Sensory Nerves Indirectly Modulate Motor Function of the Urinary Bladder.辣椒素敏感感觉神经间接调节膀胱的运动功能。
Int Neurourol J. 2018 Jun;22(2):83-89. doi: 10.5213/inj.1836078.039. Epub 2018 Jun 30.
3
Pharmacological profile of the selective β3-adrenoceptor agonist mirabegron in cynomolgus monkeys.选择性β3-肾上腺素受体激动剂米拉贝隆在食蟹猴中的药理学特性。
Naunyn Schmiedebergs Arch Pharmacol. 2013 Nov;386(11):1001-8. doi: 10.1007/s00210-013-0900-1. Epub 2013 Jul 6.
4
Neuronal circuitry of the lower urinary tract; central and peripheral neuronal control of the micturition cycle.下尿路的神经回路；排尿周期的中枢和外周神经控制。
Anat Embryol (Berl). 1995 Sep;192(3):195-209. doi: 10.1007/BF00184744.
5
Effects of phenoxybenzamine on bladder neck opening.酚苄明对膀胱颈开口的影响。
J R Soc Med. 1980 May;73(5):345-7. doi: 10.1177/014107688007300508.
6
Pharmacological characterization of the excitatory innervation to the guinea-pig urinary bladder in vitro: evidence for both cholinergic and non-adrenergic-non-cholinergic neurotransmission.豚鼠离体膀胱兴奋性神经支配的药理学特性：胆碱能和非肾上腺素能-非胆碱能神经传递的证据
Br J Pharmacol. 1981 Sep;74(1):15-22. doi: 10.1111/j.1476-5381.1981.tb09950.x.
7
Current concepts in the treatment of disorders of micturition.排尿障碍治疗的当前概念
Drugs. 1988 Apr;35(4):477-94. doi: 10.2165/00003495-198835040-00006.
8
Receptor binding studies of the flavone, REC 15/2053, and other bladder spasmolytics.黄酮类化合物REC 15/2053及其他膀胱解痉剂的受体结合研究。
Pharm Res. 1988 Jul;5(7):430-3. doi: 10.1023/a:1015936417530.
9
Sex hormones and the female urinary tract.性激素与女性泌尿系统。
Drugs. 1988 Oct;36(4):491-504. doi: 10.2165/00003495-198836040-00006.
10
alpha 1-Adrenoceptor subtype mediating contraction of the smooth muscle in the lower urinary tract and prostate of rabbits.介导兔下尿路和前列腺平滑肌收缩的α1肾上腺素能受体亚型。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Jul;330(1):16-21. doi: 10.1007/BF00586704.
本文引用的文献
1
SYMPATHETIC BETA-RECEPTORS AND THE GUINEA-PIG VAS DEFERENS.交感β受体与豚鼠输精管
Br J Pharmacol Chemother. 1965 Feb;24(1):194-204. doi: 10.1111/j.1476-5381.1965.tb02095.x.
2
Peripheral autonomic influence on the motility of the urinary bladder in the cat. II. "Tone".
Acta Physiol Scand. 1966 Jan-Feb;66(1):72-80. doi: 10.1111/j.1748-1716.1966.tb03170.x.
3
The sensitivity of adrenergic excitatory and inhibitory receptors in the smooth muscle of the rabbit urinary bladder.兔膀胱平滑肌中肾上腺素能兴奋性和抑制性受体的敏感性
Acta Pharmacol Toxicol (Copenh). 1969;27(2):213-24. doi: 10.1111/j.1600-0773.1969.tb00508.x.
4
A study of human bladder detrusor muscle.一项关于人类膀胱逼尿肌的研究。
Br J Urol. 1969 Aug;41(4):448-54. doi: 10.1111/j.1464-410x.1969.tb09946.x.
5
Relative potencies of sympathetic amines in human smooth muscle.交感胺对人体平滑肌的相对效能
Br J Pharmacol. 1969 May;36(1):213P-214P.
6
Pharmacologic studies of the nature of the sympathetic nerves of the urinary bladder.膀胱交感神经性质的药理学研究。
Paraplegia. 1968 Nov;6(3):136-50. doi: 10.1038/sc.1968.25.
7
Propranolol, MJ 1999 and Ciba 39089 Ba in ouabain and adrenaline induced cardiac arrhythmias.普萘洛尔、MJ 1999和汽巴39089 Ba对哇巴因和肾上腺素诱发的心律失常有作用。
Eur J Pharmacol. 1968 Aug;4(1):1-12. doi: 10.1016/0014-2999(68)90002-2.
8
Nervous control of urinary bladder in cats. I. The collecting phase.猫膀胱的神经控制。I. 贮尿期。
Acta Physiol Scand. 1968 Jan-Feb;72(1):157-71. doi: 10.1111/j.1748-1716.1968.tb03838.x.
9
Contractile responses of dog bladder neck muscle to adrenergic drugs.犬膀胱颈肌肉对肾上腺素能药物的收缩反应。
J Urol. 1971 May;105(5):657-61. doi: 10.1016/s0022-5347(17)61600-8.
10
The effects of cholinergic and adrenergic drug stimulation of detrusor muscle.胆碱能和肾上腺素能药物对逼尿肌的刺激作用。
Invest Urol. 1970 Nov;8(3):286-91.
Zotero 插件