Department of Physical Medicine and Rehabilitation, Ataturk University Medicine Faculty, Erzurum, Turkey.
Arch Med Sci. 2013 Aug 30;9(4):709-12. doi: 10.5114/aoms.2013.36896. Epub 2013 Aug 8.
The role of vascular endothelial growth factor (VEGF) in osteoporosis has not yet been clearly established. Vascular endothelial growth factor is an important part of bone formation. In the literature, although the effects of VEGF on bone metabolism were investigated by different studies, there are very rare studies analysing the association between osteoporosis and VEGF. In the present study, our objective was to investigate serum VEGF concentrations in patients with postmenopausal osteoporosis (PMO) and the correlation of serum VEGF levels and bone mineral density (BMD).
This study was performed on 35 PMO patients, and 30 age-matched healthy controls. Serum VEGF concentrations were measured using a quantitative sandwich enzyme immunoassay technique according to the manufacturer's instructions. Bone mineral density values were determined by dual energy X-ray absorptiometry (DEXA).
Serum VEGF concentrations were statistically significantly lower in PMO patients than in controls (150 ±65 pg/ml, 260 ±135 pg/ml respectively; p = 0.005). A positive correlation was found between serum VEGF concentrations and BMD values (r = 0.63, p = 0.001).
Vascular endothelial growth factor concentrations were decreased in PMO patients and VEGF may play an important role in bone health.
血管内皮生长因子（VEGF）在骨质疏松症中的作用尚未明确。血管内皮生长因子是骨形成的重要组成部分。在文献中，尽管不同的研究已经探讨了 VEGF 对骨代谢的影响，但很少有研究分析骨质疏松症和 VEGF 之间的关联。在本研究中，我们的目的是研究绝经后骨质疏松症（PMO）患者血清 VEGF 浓度与骨矿物质密度（BMD）的相关性。
该研究共纳入 35 名 PMO 患者和 30 名年龄匹配的健康对照者。采用定量夹心酶联免疫吸附试验技术，根据说明书测量血清 VEGF 浓度。骨矿物质密度值通过双能 X 射线吸收法（DEXA）测定。
PMO 患者血清 VEGF 浓度明显低于对照组（分别为 150±65pg/ml 和 260±135pg/ml；p=0.005）。血清 VEGF 浓度与 BMD 值呈正相关（r=0.63，p=0.001）。
PMO 患者血清 VEGF 浓度降低，VEGF 可能在骨骼健康中发挥重要作用。
