胃溃疡患者血清中循环碱性成纤维细胞生长因子作为伤口严重程度的生物标志物。

Circulating basic fibroblast growth factor in serum of gastric ulcers patient as a biomarker of wound severity.

作者信息

Shiravi Abdolhossein, Ahmadi Fariba, Parsian Hadi, Shirkhani Kelagari Ziba, Qujeq Durdi, Taheri Hassan, Kashifard Mehrdad

机构信息

Department of Biology, Islamic Azad University, Damghan Branch, Damghan, Iran.

出版信息

Caspian J Intern Med. 2011 Summer;2(3):261-5.

PMID:24049583

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3770503/

Abstract

UNLABELLED

Background : Basic fibroblast growth factor (bFGF) is a glycoprotein with stimulating ability of angiogenesis. In addition, bFGF plays an important role in wound healing process in some tissues for example gastrointestinal tract, but its ability for discrimination of various stages of wound severity in these diseases was not reported. Therefore, we aimed to determine the bFGF levels in gastric ulcer patients compared with healthy controls as a biomarker for staging the severity of wound.

METHODS

The study group consisted of 33 patients with gastric ulcer and 27 healthy controls. The diagnosis of patients was based on standard clinical, endoscopic, and histological criteria. Serum levels of bFGF were analyzed by an Elisa kit. Results : According to the histological findings, 19 (57.6%) patients were in moderate stage of ulcer and 14 (42.4%) were in the severe stage of gastric ulcer. The mean bFGF serum levels in patients group (7.8±1.3pg/ml) were lower than the healthy group (8.2±1.4pg/ml) in crude data, but in statistical analysis the differences were not significant (p=0.082). The mean bFGF serum levels in patients with severe stage of gastric ulcer were greater than the patients with moderate gastric ulcer (8.4±1.3 vs. 7.4±1.2 pg) and the differences were statistically significant (p<0.05).

CONCLUSION

The differences in serum bFGF levels in patients with severe stage of gastric ulcer vs. moderate gastric ulcer was significant. Therefore, serum bFGF level measurements can be used as a useful clinical tool for discrimination of patients with severe stage of gastric ulcer vs. moderate gastric ulcer, when endoscopic and histological examination are not possible to perform.

摘要

未标注

背景：碱性成纤维细胞生长因子（bFGF）是一种具有血管生成刺激能力的糖蛋白。此外，bFGF在某些组织如胃肠道的伤口愈合过程中起重要作用，但其在这些疾病中区分不同伤口严重程度阶段的能力尚未见报道。因此，我们旨在测定胃溃疡患者与健康对照者的bFGF水平，作为伤口严重程度分期的生物标志物。

方法

研究组由33例胃溃疡患者和27例健康对照者组成。患者的诊断基于标准的临床、内镜和组织学标准。采用酶联免疫吸附测定试剂盒分析血清bFGF水平。结果：根据组织学检查结果，19例（57.6%）患者处于溃疡中度阶段，14例（42.4%）处于胃溃疡重度阶段。在原始数据中，患者组的平均bFGF血清水平（7.8±1.3pg/ml）低于健康组（8.2±1.4pg/ml），但在统计分析中差异无统计学意义（p = 0.082）。胃溃疡重度阶段患者的平均bFGF血清水平高于中度胃溃疡患者（8.4±1.3对7.4±1.2 pg），差异有统计学意义（p < 0.05）。