Seida A, Wada J, Kunitomi M, Tsuchiyama Y, Miyatake N, Fujii M, Kira S, Takahashi K, Shikata K, Makino H
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Shikata-cho, Okayama, Japan.
Int J Obes Relat Metab Disord. 2003 Nov;27(11):1325-31. doi: 10.1038/sj.ijo.0802408.
To investigate whether the changes in vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) concentrations before and after weight reduction in Japanese overweight men are associated with changes in body mass index (BMI), visceral, subcutaneous fat, VO(2) and work rate (WR) at ventilatory threshold (VT).
Cross-sectional and longitudinal clinical intervention study with exercise education.
In total, 30 Japanese overweight men (BMI, 29.0+/-2.2 kg/m(2)) and 31 normal-weight men (BMI, 22.5+/-1.6 kg/m(2)) at baseline were enrolled: 30 overweight men (BMI, 29.0+/-2.2 kg/m(2)) were further enrolled into a 6-month exercise program.
Fat distribution evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, angiogenic peptides including VEGF and bFGF, exercise tests at baseline and after 6 months.
In normal-weight and overweight subjects at baseline, VEGF positively correlated with S area (r=0.350, P=0.007) but not with V area. In contrast, bFGF negatively correlated with BMI (r=-0.619, P<0.001), S (r=-0.457, P<0.001) and V areas (r=-0.466, P<0.001). By intervention with exercise education, 30 overweight subjects showed reduction in BMI (29.0+/-2.2 to 28.0+/-2.0, P<0.001), V and S areas, increase in VO(2) and WR at VT, increase in bFGF (9.21+/-5.82-21.2+/-7.04 ng/ml, P<0.001), and no change in VEGF (1.45+/-0.72-1.88+/-0.52 ng/ml, P=0.016). The stepwise multiple regression analysis revealed that DeltaBMI (beta=-6.052) and DeltaVO(2) (beta=2.806) were independently related to DeltabFGF (P<0.001) and all other variables including DeltaS area, and DeltaV area, and DeltaWR did not enter the equation at significant levels.
The present study indicated a negative correlation between serum bFGF levels and BMI at baseline as well as an association of DeltaBMI and DeltaVO(2) with DeltabFGF after exercise intervention. The exercise-induced elevation of bFGF may be beneficial in the prevention of the atherosclerosis in overweight subjects.
研究日本超重男性体重减轻前后血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）浓度的变化是否与体重指数（BMI）、内脏脂肪、皮下脂肪、最大摄氧量（VO₂）以及通气阈（VT）时的工作率（WR）的变化相关。
采用运动教育的横断面和纵向临床干预研究。
共纳入30名基线时的日本超重男性（BMI，29.0±2.2 kg/m²）和31名正常体重男性（BMI，22.5±1.6 kg/m²）：30名超重男性（BMI，29.0±2.2 kg/m²）进一步纳入为期6个月的运动计划。
通过脐水平计算机断层扫描测量内脏脂肪（V）和皮下脂肪（S）面积评估脂肪分布，检测血管生成肽包括VEGF和bFGF，在基线和6个月后进行运动测试。
在基线时的正常体重和超重受试者中，VEGF与S面积呈正相关（r = 0.350，P = 0.007），但与V面积无关。相反，bFGF与BMI（r = -0.619，P < 0.001）、S（r = -0.457，P < 0.001）和V面积（r = -0.466，P < 0.001）呈负相关。通过运动教育干预，30名超重受试者的BMI降低（29.0±2.2至28.0±2.0，P < 0.001），V和S面积减小，VO₂和VT时的WR增加，bFGF升高（9.21±5.82 - 21.2±7.04 ng/ml，P < 0.001），而VEGF无变化（1.45±0.72 - 1.88±0.52 ng/ml，P = 0.016）。逐步多元回归分析显示，ΔBMI（β = -6.052）和ΔVO₂（β = 2.806）与ΔbFGF独立相关（P < 0.001），包括ΔS面积、ΔV面积和ΔWR在内的所有其他变量未达到显著水平进入方程。
本研究表明基线时血清bFGF水平与BMI呈负相关，运动干预后ΔBMI和ΔVO₂与ΔbFGF相关。运动诱导的bFGF升高可能对预防超重受试者的动脉粥样硬化有益。
