Kestenbaum Thelda
Division of Dermatology, Mail Stop 2025, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.
Semin Cutan Med Surg. 2013 Jun;32(2):83-7. doi: 10.12788/j.sder.0006.
Obsessive-compulsive disorder (OCD) is a very common disorder affecting 2% to 3% of the general population. Up to 25% of patients presenting to physicians with skin disease suffer from OCD. Only 20% of all patients with OCD are receiving treatment. Unfortunately, those few receiving treatment remained undiagnosed for many years. Standard treatment includes behavioral therapy and psychotropic drugs (ie, selective serotonin re-uptake inhibitors and clomipramine). The highest dosages of these medications must be used for at least 3 months to see proper effectiveness and maintained for lengthy periods of time. Not only are there abnormalities in the serotonin pathway of patients with OCD but also the glutamate pathway is abnormal, leading to possible new treatment strategies.
强迫症（OCD）是一种非常常见的疾病，影响着2%至3%的普通人群。到皮肤科就诊的患者中，高达25%患有强迫症。所有强迫症患者中只有20%正在接受治疗。不幸的是，那些少数接受治疗的患者多年来一直未被诊断出来。标准治疗包括行为疗法和精神药物（即选择性5-羟色胺再摄取抑制剂和氯米帕明）。这些药物必须使用最高剂量至少3个月才能看到适当的疗效，并需长期维持。强迫症患者不仅5-羟色胺途径存在异常，谷氨酸途径也不正常，这可能导致新的治疗策略。
