微波辐射下快速绿色一锅法多组分合成吡咯并[1,2-c]嘧啶文库
Fast and green one-pot multicomponent synthesis of a library of pyrrolo [1,2-c] pyrimidines under microwave irradiation.
作者信息
Georgescu Emilian, Georgescu Florentina, Draghici Constantin, Cristian Liliana, Popa Marcel Mirel, Dumitrascu Florea
机构信息
Center for Organic Chemistry "C. D. Nenitzescu", Romanian Academy, Spl. Independentei 202B, Bucharest 060023, Romania.
出版信息
Comb Chem High Throughput Screen. 2013 Dec;16(10):851-7. doi: 10.2174/13862073113169990050.
A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly.
报道了一种简单、清洁且快速的一锅三组分微波辅助合成吡咯并[1,2 - c]嘧啶衍生物的方法，该方法以各种取代嘧啶、2 - 溴苯乙酮和不对称缺电子炔烃为原料，在1,2 - 环氧丁烷中进行反应，1,2 - 环氧丁烷同时作为溶剂和酸清除剂。这种一锅三组分合成法反应时间短，同时具有高成本效益和环境友好的特点。
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