Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation.
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prosp., Moscow, 119991, Russian Federation.
Chem Biodivers. 2022 Jan;19(1):e202100584. doi: 10.1002/cbdv.202100584. Epub 2021 Nov 24.
Synthesis of novel C3-substituted 5,6-dihydropyrrolo[2,1-a]isoquinolines via a three-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines, terminal alkynes and CH-acids under microwave irradiation in dry acetonitrile is described. The method developed enables the obtainment of highly functionalized compounds with pharmacophore groups, which are potentially biologically active.
通过微波辐射在干燥乙腈中的 1-芳基-3,4-二氢异喹啉、末端炔烃和 CH 酸的三组分串联反应合成新型 C3 取代的 5,6-二氢吡咯并[2,1-a]异喹啉。所开发的方法能够获得具有药效团的高度官能化化合物，这些化合物具有潜在的生物活性。
