Tampaki Ekaterini C, Tampakis Athanasios, Agrogiannis George, Kavantzas Nikolaos, Kontzoglou Konstantinos, Kouraklis Gregory
2nd Department of Propaedeutic Surgery, Athens University Medical School, Laiko General Hospital, Athens, Greece.
Onkologie. 2013;36(9):506-9. doi: 10.1159/000354638. Epub 2013 Aug 19.
Metaplastic breast cancer (MeBC) is a rare malignancy, representing less than 1% of all breast cancers. We present a case of triple-negative MeBC with a biphasic growth pattern, including malignant mesenchymal and epithelial components.
A 45-year-old female patient presented to our hospital with a 1-month history of a lump in her right breast. Upon clinical examination, a mass measuring 24 mm in diameter was revealed at 10-11 o'clock in the outer upper quadrant of the right breast. The patient was submitted for ultrasound scanning, ultrasound-guided core needle biopsy, and excisional biopsy which revealed a mixed epithelial/mesenchymal tumor, 8 cm in diameter. A complete immunohistochemical profile was presented. A right modified radical mastectomy with axillary lymph node dissection was performed and was tolerated well by the patient. The histological diagnosis of the lesion was MeBC with the epithelial component consistent with a grade 3 ductal adenocarcinoma. The 14 dissected axillary nodes were not involved. The patient was later submitted for adjuvant chemotherapy and radiotherapy. To date, 24 months postoperatively, the patient remains without any signs or symptoms of residual disease or recurrence.
The aggressive behavior and chemoresistance of MeBC warrants early diagnosis and treatment to achieve optimal outcome.
化生性乳腺癌（MeBC）是一种罕见的恶性肿瘤，占所有乳腺癌的比例不到1%。我们报告一例具有双相生长模式的三阴性MeBC病例，包括恶性间充质和上皮成分。
一名45岁女性患者因右乳肿块1个月病史前来我院就诊。临床检查发现，右乳外上象限10 - 11点处有一个直径24毫米的肿块。患者接受了超声扫描、超声引导下的粗针穿刺活检和切除活检，结果显示为一个直径8厘米的混合上皮/间充质肿瘤。给出了完整的免疫组化结果。进行了右改良根治性乳房切除术及腋窝淋巴结清扫术，患者耐受性良好。病变的组织学诊断为MeBC，上皮成分符合3级导管腺癌。14个清扫的腋窝淋巴结未受累。患者随后接受了辅助化疗和放疗。迄今为止，术后24个月，患者仍无残留疾病或复发的任何迹象或症状。
MeBC的侵袭性和化疗耐药性需要早期诊断和治疗以获得最佳结果。
