Quinto I, Tenenbaum L, Radman M
Department of Molecular Biology, Free University of Brussels, Belgium.
Mutat Res. 1990 Feb;228(2):177-85. doi: 10.1016/0027-5107(90)90074-e.
A quantitative correlation between carcinogenicity and genotoxicity was investigated by a comparison between the carcinogenic potency in rodents and the mutagenic (M), recombinogenic (R) and SOS-inducing (I) potencies in a bacterial test (E. coli multitest) for 9 monofunctional alkylating agents: N-nitroso-N-methylurethane, N-nitroso-N-ethylurea, epichlorohydrin, N-nitroso-N-methylurea, N-nitroso-N-methyl-N'-nitroguanidine, methyl methanesulfonate, diethylsulfate, dimethylsulfate, ethyl methanesulfonate. A significant positive correlation between the carcinogenic potency and the product of the mutagenic and recombinogenic potencies was found for all tested compounds. Thus, the E. coli multitest may be used as a simple test to search for correlations between carcinogenicity and genotoxicity of DNA-damaging agents.
通过比较9种单功能烷基化剂在啮齿动物中的致癌效力与在细菌试验（大肠杆菌多重试验）中的诱变（M）、重组（R）和SOS诱导（I）效力，研究了致癌性与遗传毒性之间的定量相关性。这9种单功能烷基化剂分别为：N-亚硝基-N-甲基脲、N-亚硝基-N-乙基脲、环氧氯丙烷、N-亚硝基-N-甲基脲、N-亚硝基-N-甲基-N'-硝基胍、甲磺酸甲酯、硫酸二乙酯、硫酸二甲酯、甲磺酸乙酯。对于所有测试化合物，发现致癌效力与诱变和重组效力的乘积之间存在显著的正相关。因此，大肠杆菌多重试验可作为一种简单的试验，用于寻找DNA损伤剂的致癌性与遗传毒性之间的相关性。
