侵袭性淋巴瘤中¹⁸F-FDG摄取与肿瘤增殖抗原Ki-67表达的相关性

[Correlation of ¹⁸F-FDG uptake with tumor-proliferating antigen Ki-67 expression in aggressive lymphoma].

作者信息

Liang Ying, Wu Ning, Fang Yan, Huang Wen-ting, Zhang Han, Zheng Rong, Zhang Wen-jie, Liu Ying, Li Xiao-meng

机构信息

PET-CT Center, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.

出版信息

Zhonghua Zhong Liu Za Zhi. 2013 May;35(5):356-60. doi: 10.3760/cma.j.issn.0253-3766.2013.05.008.

DOI:10.3760/cma.j.issn.0253-3766.2013.05.008

PMID:24054012

Abstract

OBJECTIVE

To investigate the correlation between ¹⁸F-FDG uptake in positron emission tomography/computed tomography imaging and tumor-proliferating antigen Ki-67 expression in aggressive lymphoma.

METHODS

Data of ¹⁸F-FDG PET-CT imaging and immunohistochemical detection of Ki-67 expression of seventy-seven cases with initially diagnosed aggressive lymphoma were retrospectively analyzed. The intensity of ¹⁸F-FDG accumulation was determined by calculating the maximum standardized uptake value (SUVmax) and average standardized uptake value (SUVave). The average SUV at biopsy site (BxSUVave), SUVmax at biopsy site (BxSUVmax) and SUVmax at the highest tumor activity site of the body (BmSUVmax) were collected.

RESULTS

The BmSUVmax, BxSUVmax, and BxSUVave were 13.4 ± 6.8, 11.9 ± 6.8 and 7.3 ± 4.4, respectively,and Ki-67 was (61.2 ± 20.4)% in the 77 aggressive lymphomas. The BmSUVmax was significantly higher than the BxSUVmax or BxSUVave (P < 0.05). The BmSUVmax, BxSUVmax and BxSUVave were positively correlated with the Ki-67 expression in aggressive lymphoma (P < 0.05). A positive correlation was revealed between the BxSUVmax and BmSUVmax (P < 0.05), and between the BxSUVmax and BxSUVave (P < 0.05). No significant correlation was found between the BmSUVmax or BxSUVmax and the Ki-67 in DLBCL (P > 0.05). A positive correlation was observed between the BmSUVmax or BxSUVmax and the Ki-67 expression in NK/T cell lymphoma (P < 0.05).

CONCLUSION

The increasing trend of ¹⁸F-FDG uptake is correlated with the Ki-67 expression in aggressive lymphoma. The results of this study suggest that the metabolic information obtained by using BmSUVmax may help to compensate the limited sampling of histological examination at the biopsy site. Significant correlation in NK/T cell lymphoma suggests that the metabolic information from positron emission tomography-computed tomography may offer a useful parameter in the prognosis and management of this disease.

摘要

目的

探讨正电子发射断层扫描/计算机断层扫描成像中¹⁸F-FDG摄取与侵袭性淋巴瘤中肿瘤增殖抗原Ki-67表达之间的相关性。

方法

回顾性分析77例初诊侵袭性淋巴瘤患者的¹⁸F-FDG PET-CT成像数据及Ki-67表达的免疫组化检测结果。通过计算最大标准化摄取值（SUVmax）和平均标准化摄取值（SUVave）来确定¹⁸F-FDG的积聚强度。收集活检部位的平均SUV（BxSUVave）、活检部位的SUVmax（BxSUVmax）以及身体最高肿瘤活性部位的SUVmax（BmSUVmax）。

结果

77例侵袭性淋巴瘤中，BmSUVmax、BxSUVmax和BxSUVave分别为13.4±6.8、11.9±6.8和7.3±4.4，Ki-67为（61.2±20.4）%。BmSUVmax显著高于BxSUVmax或BxSUVave（P<0.05）。侵袭性淋巴瘤中，BmSUVmax、BxSUVmax和BxSUVave与Ki-67表达呈正相关（P<0.05）。BxSUVmax与BmSUVmax之间呈正相关（P<0.05），BxSUVmax与BxSUVave之间也呈正相关（P<0.05）。在弥漫大B细胞淋巴瘤（DLBCL）中，BmSUVmax或BxSUVmax与Ki-67之间未发现显著相关性（P>0.05）。在NK/T细胞淋巴瘤中，BmSUVmax或BxSUVmax与Ki-67表达呈正相关（P<0.05）。