Zhang Jianhua, Wang Rongfu, Fan Yan, Fu Zhanli, Zhang Xuchu, Liao Xuhe, Liu Meng, Kang Lei, Cui Yonggang, Wang Yanfu, Jiang Qiao
Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.
Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China. Email:
Zhonghua Yi Xue Za Zhi. 2014 Sep 9;94(33):2576-9.
To compare the metabolic activity by ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) uptake across the various histologic subtypes of non-Hodgkin lymphoma (NHL) and to investigate the relationship between metabolic activity and immunophenotype.
Positron emission tomography/computed tomography (PET/CT) studies of patients with newly diagnosed NHL from Jul 2010 to Mar 2012 were retrospectively reviewed, 82 patients were enrolled in our study according to the inclusion and exclusion criteria. The maximum standardized uptake value (SUVmax) of each patient reflecting the metabolic activity was recorded. Mean SUVmax of aggressive B-cell NHL, indolent B-cell NHL and T-cell NHL were compared. Pearson and Spearman test were used to analyze the relationship between SUVmax and immunophenotype.
The SUVmax of various subtypes of lymphoma revealed a wide range from 0.9 to 40.3, but lesions of 79 patients in this study showed obviously FDG uptake. SUVmax of indolent B-cell NHL (4.5 ± 2.4) was significantly lower than that of aggressive B-cell NHL (13.1 ± 7.6) (P = 0.000), T-cell NHL (8.0 ± 3.8) (P = 0.03). SUVmax of aggressive B-cell NHL was significantly higher than that of indolent B-cell NHL, T-cell NHL (P = 0.000, P = 0.005). SUVmax of B-cell NHL had positive correlation with Ki-67 expression (r = 0.493, P = 0.001) and negative correlation with CD138 (r = -0.654, P = 0.008). While SUVmax of T-cell NHL had no correlation with Ki-67 expression (P = 0.213), but had negative correlation with CD56 (r = -0.545, P = 0.044).
Different subtype of NHL manifests markedly different intensity of FDG uptake, but most lesions of lymphoma are FDG avid. Metabolic activity is lower in indolent B-cell NHL than in aggressive B-cell NHL and T-cell lymphoma, which is concordant with its aggressiveness. SUVmax of B-cell NHL correlates with expression of Ki-67 and CD138. SUVmax of T-cell NHL is associated with the expression of CD56, no correlation is detected between SUVmax of T-cell NHL and Ki-67 proliferation.
通过¹⁸F-氟脱氧葡萄糖（¹⁸F-FDG）摄取情况比较非霍奇金淋巴瘤（NHL）不同组织学亚型的代谢活性，并研究代谢活性与免疫表型之间的关系。
回顾性分析2010年7月至2012年3月新诊断的NHL患者的正电子发射断层扫描/计算机断层扫描（PET/CT）研究，根据纳入和排除标准纳入82例患者。记录反映代谢活性的每位患者的最大标准化摄取值（SUVmax）。比较侵袭性B细胞NHL、惰性B细胞NHL和T细胞NHL的平均SUVmax。采用Pearson和Spearman检验分析SUVmax与免疫表型之间的关系。
淋巴瘤各亚型的SUVmax范围为0.9至40.3，但本研究中79例患者的病变显示明显的FDG摄取。惰性B细胞NHL的SUVmax（4.5±2.4）显著低于侵袭性B细胞NHL（13.1±7.6）（P = 0.000）、T细胞NHL（8.0±3.8）（P = 0.03）。侵袭性B细胞NHL的SUVmax显著高于惰性B细胞NHL、T细胞NHL（P = 0.000，P = 0.005）。B细胞NHL的SUVmax与Ki-67表达呈正相关（r = 0.493，P = 0.001），与CD138呈负相关（r = -0.654，P = 0.008）。而T细胞NHL的SUVmax与Ki-67表达无相关性（P = 0.213），但与CD56呈负相关（r = -0.545，P = 0.044）。
NHL不同亚型表现出明显不同的FDG摄取强度，但大多数淋巴瘤病变对FDG摄取较高。惰性B细胞NHL的代谢活性低于侵袭性B细胞NHL和T细胞淋巴瘤，这与其侵袭性一致。B细胞NHL的SUVmax与Ki-67和CD138的表达相关。T细胞NHL的SUVmax与CD56的表达相关，T细胞NHL的SUVmax与Ki-67增殖之间未检测到相关性。
