白细胞介素1基因多态性与系统性红斑狼疮易感性的关联：一项荟萃分析。

Associations between interleukin 1 polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis.

作者信息

Song Gwan Gyu, Kim Jae-Hoon, Seo Young Ho, Choi Sung Jae, Ji Jong Dae, Lee Young Ho

机构信息

Division of Rheumatology, Department of Internal Medicine, Korea University, College of Medicine, Seoul, Republic of Korea.

出版信息

Hum Immunol. 2014 Jan;75(1):105-12. doi: 10.1016/j.humimm.2013.09.002. Epub 2013 Sep 17.

DOI:10.1016/j.humimm.2013.09.002

PMID:24055697

Abstract

OBJECTIVE

This study determined whether interleukin 1 (IL1) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE).

METHODS

A meta-analysis was conducted on the associations between the IL1A, IL1B, and IL1 receptor antagonist (IL1RN) polymorphisms and SLE.

RESULTS

A total of 15 studies involving 1956 SLE cases and 2347 controls were included in the meta-analysis. The meta-analysis showed an association between SLE and the IL1A -889 T allele in the overall population and Europeans (OR = 0.858, 95% CI = 0.737-0.986, p = 0.032; OR = 0.827, 95% CI = 0.687-0.994, p = 0.043). Meta-analysis of the IL1RN polymorphism revealed an association with SLE in all study subjects (OR for IL1RN*2 = 1.539, 95% CI = 1.266-1.871, p = 1.5 × 10(-2)) and in Europeans and Asians (OR = 1.483, 95% CI = 1.187-1.852, p = 0.001; OR = 1.787, 95% CI = 1.167-2.736, p=0.008). No associations were found between SLE and the IL1B -511 C/T, 3953 C/T, and IL1A +4845 G/T polymorphisms.

CONCLUSIONS

This meta-analysis suggests IL1A -889 C/T polymorphism is associated with susceptibility to SLE in Europeans, and that the IL1RN*2 allele is associated with susceptibility to SLE in Europeans and Asians.

摘要

目的

本研究旨在确定白细胞介素1（IL1）基因多态性是否与系统性红斑狼疮（SLE）易感性相关。

方法

对IL1A、IL1B和白细胞介素1受体拮抗剂（IL1RN）基因多态性与SLE之间的关联进行荟萃分析。

结果

荟萃分析共纳入15项研究，涉及1956例SLE患者和2347例对照。荟萃分析显示，在总体人群和欧洲人中，SLE与IL1A -889 T等位基因相关（OR = 0.858，95% CI = 0.737 - 0.986，p = 0.032；OR = 0.827，95% CI = 0.687 - 0.994，p = 0.043）。对IL1RN基因多态性的荟萃分析显示，在所有研究对象中（IL1RN*2的OR = 1.539，95% CI = 1.266 - 1.871，p = 1.5×10⁻²）以及在欧洲人和亚洲人中（OR = 1.483，95% CI = 1.187 - 1.852，p = 0.001；OR = 1.787，95% CI = 1.167 - 2.736，p = 0.008），IL1RN基因多态性与SLE相关。未发现SLE与IL1B -511 C/T、3953 C/T以及IL1A +4845 G/T基因多态性之间存在关联。