Questions about DISC1 as a genetic risk factor for schizophrenia.
作者信息
Sullivan P F
机构信息
Departments of Genetics and Psychiatry, Center for Psychiatric Genomics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
出版信息
Mol Psychiatry. 2013 Oct;18(10):1050-2. doi: 10.1038/mp.2012.182.
Abstract
摘要
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Questions about DISC1 as a genetic risk factor for schizophrenia.关于DISC1作为精神分裂症遗传风险因素的问题。
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Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder.精神分裂症1基因和精神分裂症2基因多态性的鉴定及其与精神分裂症和双相情感障碍相关性的研究
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1
De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia.从头突变基因突显精神分裂症遗传和神经复杂性的模式。
Nat Genet. 2012 Dec;44(12):1365-9. doi: 10.1038/ng.2446. Epub 2012 Oct 3.
2
Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia.外显子组测序结合大规模基因分型提示，中度罕见且具有强效应的风险因素在精神分裂症中的作用有限。
Am J Hum Genet. 2012 Aug 10;91(2):303-12. doi: 10.1016/j.ajhg.2012.06.018. Epub 2012 Aug 2.
3
Genetic architectures of psychiatric disorders: the emerging picture and its implications.精神障碍的遗传结构：新兴的图景及其影响。
Nat Rev Genet. 2012 Jul 10;13(8):537-51. doi: 10.1038/nrg3240.
4
Patterns and rates of exonic de novo mutations in autism spectrum disorders.自闭症谱系障碍中基因外显子新生突变的模式和速率。
Nature. 2012 Apr 4;485(7397):242-5. doi: 10.1038/nature11011.
5
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.散发性自闭症外显子组揭示了从头突变的高度相互关联的蛋白质网络。
Nature. 2012 Apr 4;485(7397):246-50. doi: 10.1038/nature10989.
6
De novo mutations revealed by whole-exome sequencing are strongly associated with autism.全外显子组测序揭示的新生突变与自闭症强烈相关。
Nature. 2012 Apr 4;485(7397):237-41. doi: 10.1038/nature10945.
7
Deep resequencing and association analysis of schizophrenia candidate genes.精神分裂症候选基因的深度重测序与关联分析
Mol Psychiatry. 2013 Feb;18(2):138-40. doi: 10.1038/mp.2012.28. Epub 2012 Apr 3.
8
Aggregated proteins in schizophrenia and other chronic mental diseases: DISC1opathies.精神分裂症和其他慢性精神疾病中的聚集蛋白：DISC1 病。
Prion. 2012 Apr-Jun;6(2):134-41. doi: 10.4161/pri.18989. Epub 2012 Apr 1.
9
A systematic survey of loss-of-function variants in human protein-coding genes.人类蛋白编码基因功能丧失变异的系统调查。
Science. 2012 Feb 17;335(6070):823-8. doi: 10.1126/science.1215040.
10
DISC1 at 10: connecting psychiatric genetics and neuroscience.DISC1 于 10 点：连接精神遗传学和神经科学。
Trends Mol Med. 2011 Dec;17(12):699-706. doi: 10.1016/j.molmed.2011.09.002. Epub 2011 Oct 19.
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