Góth Miklós
Magyar Honvédség Egészségügyi Központ II. Belgyógyászati Osztály, Endokrinológiai Szakprofil Budapest Podmaniczky u. 111. 1062.
Orv Hetil. 2013 Sep 29;154(39):1527-34. doi: 10.1556/OH.2013.29719.
Prolonged overproduction of growth hormone, like insulin-like growth factor-1 hypersecretion leads to acromegaly in adults. This is associated with several co-morbidities and increased mortality. Despite typical clinical features and modern diagnostic tools, it often takes years to diagnose from the onset of the disease. The aims of the treatment are to reduce or control tumour growth, inhibit growth hormone hypersecretion, normalize insulin-like growth factor-1 levels, treat co-morbidities and, therefore, reduce mortality. There are three approaches for therapy: surgery, medical management (dopamine agonists, somatostatin analogues and growth hormone receptor antagonist), and radiotherapy. Efficient therapy of the disease is based on the appropriate multidisciplinary team management. The review provides a summary of medical treatment for acromegaly.
生长激素长期过度分泌，如胰岛素样生长因子-1分泌过多，会导致成年人患肢端肥大症。这与多种合并症及死亡率增加有关。尽管有典型的临床特征和现代诊断工具，但从疾病发作到确诊往往需要数年时间。治疗的目的是减少或控制肿瘤生长、抑制生长激素过度分泌、使胰岛素样生长因子-1水平正常化、治疗合并症，从而降低死亡率。有三种治疗方法：手术、药物治疗（多巴胺激动剂、生长抑素类似物和生长激素受体拮抗剂）和放射治疗。该疾病的有效治疗基于适当的多学科团队管理。本综述总结了肢端肥大症的药物治疗。
