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[骨髓间充质干细胞与其他骨髓内细胞相互作用的研究进展]

[Progress of research on interaction between bone marrow mensenchymal stem cell and other intra-bone marrow cells].

作者信息

Yan Hao, Chen Tong

机构信息

Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2013 Aug;30(4):889-93.

PMID:24059076
Abstract

Bone marrow mensenchymal stem cells (BM-MSCs) are capable of supporting the survival, differentiation and migration of hematopoietic stem cell, and have a profound application prospect in transplantation and treatment of graft-versus-host disease (GVHD). This review aims to illustrate the interaction between BM-MSCs and other intra-bone marrow cells, including hematopoietic stem cells, endothelial cells and osteoblasts. The investigation of their regulating mechanism will help better understanding of the BM-MSCs' role in hematopoiesis.

摘要

骨髓间充质干细胞（BM-MSCs）能够支持造血干细胞的存活、分化和迁移，在移植物抗宿主病（GVHD）的移植和治疗中具有广阔的应用前景。本综述旨在阐述BM-MSCs与其他骨髓内细胞（包括造血干细胞、内皮细胞和成骨细胞）之间的相互作用。对其调控机制的研究将有助于更好地理解BM-MSCs在造血过程中的作用。

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