衰老肾脏的病理生理学

Pathophysiology of the aging kidney.

作者信息

Gilbert B R, Vaughan E D

机构信息

James Buchanan Brady Foundation, Department of Surgery, New York Hospital-Cornell Medical Center, New York.

出版信息

Clin Geriatr Med. 1990 Feb;6(1):13-30.

PMID:2405974

Abstract

It is the alterations in renal function associated with age that necessitate physicians treating geriatric patients to have an understanding of the fragile senescent kidney. This article examines the physiologic impact of the aging kidney on homeostasis and includes a discussion of altered pharmacodynamics occurring with impaired renal function. We also discuss the limitations of various quantitative methods of measuring renal function and present several "bedside techniques" for the assessment of renal function.

摘要

正是与年龄相关的肾功能改变，使得治疗老年患者的医生有必要了解脆弱的衰老肾脏。本文探讨了衰老肾脏对体内平衡的生理影响，并讨论了肾功能受损时发生的药效学改变。我们还讨论了各种测量肾功能定量方法的局限性，并介绍了几种评估肾功能的“床边技术”。