Lonergan E T
Geriatric Section, San Francisco Veterans Administration Medical Center.
Geriatrics. 1988 Mar;43(3):27-30, 32-3.
Changes in renal physiology and function with aging--eg, morphologic changes, decreased renal blood flow, altered glomerular filtration rate, and blunted tubule response--put the elderly patient at higher risk for adverse effects of drug therapy and for undertreatment. A thorough understanding of the many age-related alterations in kidney function will lead to the selection of appropriate therapy for elderly patients and, thus, the prevention of common problems such as volume depletion, infection, hyponatremia, metabolic acidosis, and excessive dosing.
随着年龄增长，肾脏生理和功能会发生变化，例如形态学改变、肾血流量减少、肾小球滤过率改变以及肾小管反应减弱，这使得老年患者更易受到药物治疗不良反应和治疗不足的影响。深入了解与年龄相关的多种肾功能改变，将有助于为老年患者选择合适的治疗方法，从而预防诸如容量耗竭、感染、低钠血症、代谢性酸中毒和用药过量等常见问题。
