Institute for Virus Research, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Curr Opin Virol. 2013 Dec;3(6):684-91. doi: 10.1016/j.coviro.2013.08.010. Epub 2013 Sep 21.
Human T-cell leukemia virus type 1 (HTLV-1) spreads primarily by cell-to-cell transmission. Therefore, HTLV-1 promotes the proliferation of infected cells to facilitate transmission. In HTLV-1 infected individuals, the provirus is present mainly in effector/memory T cells and Foxp3+ T cells. Recent study suggests that this immunophenotype is acquired by infected cells through the function of HTLV-1 bZIP factor (HBZ). Tax, which is encoded by the plus strand, is crucial for viral replication and de novo infection, while HBZ, encoded by the minus strand, is important for proliferation of infected cells. Importantly, HBZ and Tax have opposing functions in most transcription pathways. HBZ and Tax cooperate in elaborate ways to permit viral replication, proliferation of infected cells and propagation of the virus.
人 T 细胞白血病病毒 1 型（HTLV-1）主要通过细胞间传播。因此，HTLV-1 促进受感染细胞的增殖以促进传播。在 HTLV-1 感染个体中，前病毒主要存在于效应/记忆 T 细胞和 Foxp3+T 细胞中。最近的研究表明，这种免疫表型是通过 HTLV-1 bZIP 因子（HBZ）的功能获得的。由正链编码的 Tax 对于病毒复制和新感染至关重要，而由负链编码的 HBZ 对于受感染细胞的增殖很重要。重要的是，HBZ 和 Tax 在大多数转录途径中具有相反的功能。HBZ 和 Tax 以精细的方式合作，以允许病毒复制、受感染细胞的增殖和病毒的传播。
