García-Barros Mónica, Coant Nicolas, Truman Jean-Philip, Snider Ashley J, Hannun Yusuf A
Department of Medicine and the Stony Brook Cancer Center, Health Science Center, Stony Brook University, 101 Nicolls Road, T15, 023, 11794, Stony Brook, NY, USA.
VAMC Northport, 79 Middleville Road, Northport, NY, USA, Health Science Center, Stony Brook University, Stony Brook, NY, USA.
Biochim Biophys Acta. 2014 May;1841(5):773-82. doi: 10.1016/j.bbalip.2013.09.007. Epub 2013 Sep 21.
Colorectal cancer is one of the major causes of death in the western world. Despite increasing knowledge of the molecular signaling pathways implicated in colon cancer, therapeutic outcomes are still only moderately successful. Sphingolipids, a family of N-acyl linked lipids, have not only structural functions but are also implicated in important biological functions. Ceramide, sphingosine and sphingosine-1-phosphate are the most important bioactive lipids, and they regulate several key cellular functions. Accumulating evidence suggests that many cancers present alterations in sphingolipids and their metabolizing enzymes. The aim of this review is to discuss the emerging roles of sphingolipids, both endogenous and dietary, in colon cancer and the interaction of sphingolipids with WNT/β-catenin pathway, one of the most important signaling cascades that regulate development and homeostasis in intestine. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology.
结直肠癌是西方世界主要的死亡原因之一。尽管对结肠癌相关分子信号通路的了解不断增加，但治疗效果仍然只是取得了一定程度的成功。鞘脂是一类N-酰基连接的脂质，不仅具有结构功能，还参与重要的生物学功能。神经酰胺、鞘氨醇和1-磷酸鞘氨醇是最重要的生物活性脂质，它们调节多种关键的细胞功能。越来越多的证据表明，许多癌症存在鞘脂及其代谢酶的改变。本综述的目的是讨论内源性和膳食鞘脂在结肠癌中的新作用，以及鞘脂与WNT/β-连环蛋白信号通路的相互作用，WNT/β-连环蛋白信号通路是调节肠道发育和内环境稳定的最重要信号级联之一。本文是名为“鞘脂生物学新前沿”的特刊的一部分。
