Alqahtani Mohammad, AlKhtaami Ali, AlGobain Mohammed, Aljohani Naji, Bin Salih A, AlShalati Fatimah, Alanazi Thari
Dr. Mohammad Alqahtani, King Abdulaziz Medical City,, PO Box 22490, Riyadh 11426, Saudi Arabia,
Ann Saudi Med. 2013 Jul-Aug;33(4):387-91. doi: 10.5144/0256-4947.2013.387.
Studies about stroke in Saudi Arabia are limited. This retrospective study aims to determine the clinical characteristics of Saudi patients with heart failure (HF) with and without subsequent stroke, and also to find out whether gender differences exist in the presentation of HF patients who had stroke.
Retrospective study done at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia, from 2002-2008.
A total of 293 patient (151 males, 142 females) charts from 2002-2008 were re.viewed at KAMC. These charts were from Saudi patients who were diagnosed with HF, with and without subsequent stroke. Demographics, HF characteristics, stroke risk factors, and metabolic characteristics were noted and analyzed.
No difference was observed in HF characteristics and stroke risk factors among HF patients with and without subsequent stroke. In terms of metabolic profile, those who had stroke had significantly higher low-density lipoprotein (LDL)--cholesterol levels as compared to those without (P=.03). Stratification to gender and adjusting for age and risk factors revealed that significantly higher LDL-cholesterol and total cholesterol levels were observed in female stroke patients (P values .02, .028, respectively) and significantly higher blood urea nitrogen levels were observed in male stroke patients (P=.04) as compared to their counterparts who never had a stroke.
The gender differences in the metabolic presentation of Saudi HF patients with stroke warrant further clinical investigation. Atherogenic dyslipidemia and renal insufficiency are suggested to be early predic.tors for stroke and should be closely monitored in Saudi HF patients.
沙特阿拉伯关于中风的研究有限。这项回顾性研究旨在确定患有和未患中风的沙特心力衰竭（HF）患者的临床特征，并找出中风的HF患者在临床表现上是否存在性别差异。
在沙特阿拉伯利雅得的阿卜杜勒阿齐兹国王医疗城（KAMC）进行的回顾性研究，时间跨度为2002年至2008年。
2002年至2008年期间，KAMC共查阅了293例患者（151例男性，142例女性）的病历。这些病历来自被诊断为HF且患有或未患中风的沙特患者。记录并分析了人口统计学、HF特征、中风危险因素和代谢特征。
在患有和未患中风的HF患者中，HF特征和中风危险因素方面未观察到差异。在代谢谱方面，与未患中风的患者相比，患中风的患者低密度脂蛋白（LDL）胆固醇水平显著更高（P = 0.03）。按性别分层并调整年龄和危险因素后发现，与从未患过中风的女性患者相比，女性中风患者的LDL胆固醇和总胆固醇水平显著更高（P值分别为0.02、0.028），与从未患过中风的男性患者相比，男性中风患者的血尿素氮水平显著更高（P = 0.04）。
沙特中风HF患者在代谢表现上的性别差异值得进一步临床研究。动脉粥样硬化性血脂异常和肾功能不全被认为是中风的早期预测因素，在沙特HF患者中应密切监测。
