Departamento Biomédico, Orientación Fisiología, Facultad de Medicina, Universidad Nacional de Tucumán, INSIBO-CONICET, Hospital del Niño Jesús, Tucumán, Argentina.
Horm Res Paediatr. 2013;80(4):281-6. doi: 10.1159/000354991. Epub 2013 Sep 19.
Obesity is related to an increase in the rates of cardiovascular disease.
To establish the impact of obesity on vascular function (endothelial function and arterial stiffness) in children and adolescents and its relationship to cardiovascular risk factors.
In obese (OB) children and adolescents, endothelial function and arterial stiffness were evaluated by a pulse plethysmography method (reactive hyperemia and index of digital volume waveforms, respectively). Data were compared with the non-obese (non-OB) group (body mass index >10th to <97th percentile). Anthropometric parameters, body fat percentage, fasting glucose, lipid profile, insulinemia, HOMA-IR and hemodynamic parameters were determined in both groups.
Body mass index, weight, waist circumference, body fat, insulinemia and HOMA-IR were significantly higher in the OB group. The OB group showed impaired endothelial function (15.8 ± 0.2%, n = 37) compared to the non-OB group (41.4 ± 5%, n = 20; p < 0.001) and increased arterial stiffness. Endothelial function was only negatively correlated with waist circumference and HOMA-IR in the OB group, whereas a positive correlation was found between insulinemia and HOMA-IR.
This study shows that impaired vascular function is already present in OB children and adolescents. The fact that obesity is associated with some markers of cardiovascular risk suggests the importance of early lifestyle interventions in this population to prevent cardiovascular disease.
肥胖与心血管疾病发病率的增加有关。
确定肥胖对儿童和青少年血管功能（内皮功能和动脉僵硬度）的影响及其与心血管危险因素的关系。
通过脉搏体积描记法评估肥胖（OB）儿童和青少年的内皮功能和动脉僵硬度（分别为反应性充血和数字容积波指数）。将数据与非肥胖（非 OB）组（体重指数>第 10 百分位至<第 97 百分位）进行比较。在两组中均测定了人体测量参数、体脂百分比、空腹血糖、血脂谱、胰岛素血症、HOMA-IR 和血液动力学参数。
OB 组的体重指数、体重、腰围、体脂、胰岛素血症和 HOMA-IR 显著升高。与非 OB 组（41.4 ± 5%，n = 20）相比，OB 组的内皮功能受损（15.8 ± 0.2%，n = 37；p < 0.001），且动脉僵硬度增加。在 OB 组中，内皮功能仅与腰围和 HOMA-IR 呈负相关，而胰岛素血症与 HOMA-IR 呈正相关。
本研究表明，血管功能受损在肥胖的儿童和青少年中已经存在。肥胖与某些心血管危险因素标志物相关，这表明在该人群中早期进行生活方式干预对于预防心血管疾病的重要性。
