Tai Evelyn Li Min, Kueh Yee Cheng, Wan Hitam Wan-Hazabbah, Wong Tien Yin, Shatriah Ismail
Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
PLoS One. 2018 Feb 1;13(2):e0191434. doi: 10.1371/journal.pone.0191434. eCollection 2018.
Childhood obesity is associated with adult cardiometabolic disease. We postulate that the underlying microvascular dysfunction begins in childhood. We thus aimed to compare retinal vascular parameters between obese and non-obese children.
This was a cross-sectional study involving 166 children aged 6 to 12 years old in Malaysia. Ocular examination, biometry, retinal photography, blood pressure and body mass index measurement were performed. Participants were divided into two groups; obese and non-obese. Retinal vascular parameters were measured using validated software.
Mean age was 9.58 years. Approximately 51.2% were obese. Obese children had significantly narrower retinal arteriolar caliber (F(1,159) = 6.862, p = 0.010), lower arteriovenous ratio (F(1,159) = 17.412, p < 0.001), higher venular fractal dimension (F(1,159) = 4.313, p = 0.039) and higher venular curvature tortuosity (F(1,158) = 5.166, p = 0.024) than non-obese children, after adjustment for age, gender, blood pressure and axial length.
Obese children have abnormal retinal vascular geometry. These findings suggest that childhood obesity is characterized by early microvascular abnormalities that precede development of overt disease. Further research is warranted to determine if these parameters represent viable biomarkers for risk stratification in obesity.
儿童肥胖与成人心脏代谢疾病相关。我们推测潜在的微血管功能障碍始于儿童期。因此，我们旨在比较肥胖和非肥胖儿童的视网膜血管参数。
这是一项横断面研究，涉及马来西亚166名6至12岁的儿童。进行了眼部检查、生物测量、视网膜摄影、血压测量和体重指数测量。参与者分为两组：肥胖组和非肥胖组。使用经过验证的软件测量视网膜血管参数。
平均年龄为9.58岁。约51.2%为肥胖儿童。在调整年龄、性别、血压和眼轴长度后，肥胖儿童的视网膜小动脉管径明显更窄（F(1,159)=6.862，p=0.010），动静脉比更低（F(1,159)=17.412，p<0.001），小静脉分形维数更高（F(1,159)=4.313，p=0.039），小静脉曲率扭曲度更高（F(1,158)=5.166，p=0.024）。
肥胖儿童存在异常的视网膜血管形态。这些发现表明，儿童肥胖的特征是在明显疾病发生之前就存在早期微血管异常。有必要进一步研究以确定这些参数是否代表肥胖风险分层的可行生物标志物。
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