Department of Medicine, Gastroenterology Division, University of Pennsylvania Perelman School of Medicine, 913 Biomedical Research Building II/III, 421 Curie Boulevard, Philadelphia PA 19104-6144, USA.
Nat Rev Cancer. 2013 Oct;13(10):701-13. doi: 10.1038/nrc3582.
Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.
Krüppel 样因子 (KLFs) 是一类 DNA 结合转录调控因子家族，在多种细胞过程中具有多样化且至关重要的功能，包括增殖、分化、迁移、炎症和多能性。在这篇综述中，我们讨论了 17 种已知的 KLFs 在各种与癌症相关的过程中的作用和调节。重要的是，KLFs 的功能具有上下文依赖性，一些 KLFs 在正常细胞和癌细胞中、在癌症的发生和发展过程中以及在不同的癌症类型中具有不同的作用。我们还确定了该领域的关键问题，这些问题很可能导致癌症生物学领域的重要新转化研究和发现。
