Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles (ULB), 808 route de Lennik, 1070 Brussels, Belgium.
Nat Rev Cancer. 2013 Oct;13(10):727-38. doi: 10.1038/nrc3597.
The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro clonogenic assays, transplantation and in vivo lineage tracing, have been used to assess the renewing and differentiation potential of normal SCs. Similar strategies have suggested that solid tumours may also be hierarchically organized and contain cancer SCs (CSCs) that sustain tumour growth and relapse after therapy. In this Opinion article, we discuss the different parallels that can be drawn between adult SCs and CSCs in solid tumours.
许多成人组织的维持和修复是由干细胞（SCs）来保证的，这些干细胞位于这些组织的细胞层次结构的顶端。功能测定，如体外集落形成测定、移植和体内谱系追踪，已被用于评估正常SCs 的更新和分化潜能。类似的策略表明，实体瘤也可能是分级组织的，并且包含维持肿瘤生长和治疗后复发的癌症干细胞（CSCs）。在这篇观点文章中，我们讨论了实体瘤中成人SCs 和 CSCs 之间可以得出的不同相似之处。
