University of Nebraska Medical Center, Department of Pathology and Microbiology, 986495 Nebraska Medical Center, Omaha NE 68198-6495, USA.
Nat Rev Cancer. 2013 Oct;13(10):739-52. doi: 10.1038/nrc3581.
Tumour-induced granulocytic hyperplasia is associated with tumour vasculogenesis and escape from immunity via T cell suppression. Initially, these myeloid cells were identified as granulocytes or monocytes; however, recent studies have revealed that this hyperplasia is associated with populations of multipotent progenitor cells that have been identified as myeloid-derived suppressor cells (MDSCs). The study of MDSCs has provided a wealth of information regarding tumour pathobiology, has extended our understanding of neoplastic progression and has modified our approaches to immune adjuvant therapy. In this Timeline article, we discuss the history of MDSCs, their influence on tumour progression and metastasis, and the crosstalk between tumour cells, MDSCs and the host macroenvironment.
肿瘤诱导的粒细胞增生与肿瘤血管生成和通过 T 细胞抑制逃避免疫有关。最初，这些髓系细胞被鉴定为粒细胞或单核细胞;然而，最近的研究表明，这种增生与多能祖细胞群体有关，这些祖细胞已被鉴定为髓系来源的抑制细胞（MDSCs）。MDSCs 的研究提供了大量有关肿瘤病理生物学的信息，扩展了我们对肿瘤进展的理解，并改变了我们对免疫佐剂治疗的方法。在这篇时间线文章中，我们讨论了 MDSCs 的历史、它们对肿瘤进展和转移的影响，以及肿瘤细胞、MDSCs 和宿主宏观环境之间的串扰。
