Department of Hematology and Oncology, Konan Kosei Hospital, 137 Oomatsubara, Takaya-cho, Konan-city, Aichi, 483-8704, Japan,
Int J Hematol. 2013 Nov;98(5):620-4. doi: 10.1007/s12185-013-1431-8. Epub 2013 Sep 24.
We describe the case of a 70-year-old male with acromegaly who developed colon carcinoma and myelodysplastic syndrome (MDS) during the course of acromegaly. MDS progressed to acute myeloid leukemia, but was refractory to chemotherapy. Acromegaly is a rare disorder caused by excessive amounts of growth hormone (GH) primarily secreted by pituitary adenomas. Patients with acromegaly are more prone to develop various malignancies, but there are few reports of hematological malignancies in such patients. In the present case, excessive endogenous GH and insulin-like growth factor-I levels may have altered cell proliferation and thereby affected the oncogenesis and chemosensitivity of both malignancies.
我们描述了一例肢端肥大症患者的病例，该患者在肢端肥大症的病程中发展为结肠癌和骨髓增生异常综合征（MDS）。MDS 进展为急性髓系白血病，但对化疗有抗药性。肢端肥大症是一种由垂体腺瘤主要分泌的生长激素（GH）过量引起的罕见疾病。肢端肥大症患者更容易患上各种恶性肿瘤，但此类患者中很少有血液恶性肿瘤的报告。在本病例中，过多的内源性 GH 和胰岛素样生长因子-I 水平可能改变了细胞增殖，从而影响了两种恶性肿瘤的发生和化疗敏感性。
