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Acute promyelocytic leukemia in the course of acromegaly: a case report.

作者信息

Beyan C, Ural A U, Cetin T, Ozata M, Yalçin A

机构信息

Hematology Department, Gülhane Military Medical Faculty, Ankara, Turkey.

出版信息

Endocr J. 1996 Oct;43(5):565-8. doi: 10.1507/endocrj.43.565.

DOI:10.1507/endocrj.43.565
PMID:8980897
Abstract

Acromegaly is an uncommon disease due to excessive amounts of growth hormone. Benign and malignant tumors have been reported in acromegalic patients. A 41-year-old female patient who had been followed up because of acromegaly by the endocrinology department for two years, was admitted to the hematology department for the evaluation of pancytopenia and the related signs and symptoms. Dopamine agonists were being used till a diagnosis of 'acute promyelocytic leukemia' was made. Occurrence of 'acute promyelocytic leukemia' in the course of acromegaly may have been caused by excessive endogenous GH or may be a coincidental situation.

摘要

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The growth hormone receptor interacts with its sheddase, the tumour necrosis factor-alpha-converting enzyme (TACE).生长激素受体与其裂解酶——肿瘤坏死因子-α转化酶(TACE)相互作用。
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