Gandolfi S A
Istituto di Oftalmologia, Università di Parma, Italy.
Invest Ophthalmol Vis Sci. 1990 Feb;31(2):354-8.
In a prospective randomized single-masked study lasting 6 months, 39 eyes with primary open-angle glaucoma showing a long-term drift with 0.5% timolol were put on a "timolol holiday" lasting 30 or 60 days. Twenty-three of them were enrolled with dipivefrin 0.1% twice daily during the holiday. When timolol therapy was restored, the dipivefrin-treated group showed a more pronounced decrease of intraocular pressure (IOP) (8.2 +/- 1.5), whereas the IOP decrease in the nondipivefrin-treated group was lower (3.9 +/- 1.2) and of shorter duration (less than 60 days). Among the dipivefrin-treated group, the response to timolol was more prolonged in the eyes treated for 60 days: the IOP of these eyes was less than 23 mmHg throughout the follow-up.
在一项为期6个月的前瞻性随机单盲研究中，39只使用0.5%噻吗洛尔出现长期眼压漂移的原发性开角型青光眼患眼进入了为期30天或60天的“噻吗洛尔假期”。其中23只患眼在假期中每天两次使用0.1%的地匹福林。当恢复噻吗洛尔治疗时，地匹福林治疗组的眼压（IOP）下降更为显著（8.2±1.5），而未用地匹福林治疗组的眼压下降幅度较小（3.9±1.2）且持续时间较短（少于60天）。在地匹福林治疗组中，接受60天治疗的患眼对噻吗洛尔的反应更持久：在整个随访期间，这些患眼的眼压均低于23 mmHg。
