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Topical timolol 0.5% gel-forming solution for erythema in rosacea: A quantitative, split-face, randomized, and rater-masked pilot clinical trial.

作者信息

Tsai Jerry, Chien Anna L, Kim Noori, Rachidi Saleh, Connolly Brian M, Lim Hester, Alessi César Sabrina Sisto, Kang Sewon, Garza Luis A

机构信息

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

出版信息

J Am Acad Dermatol. 2021 Oct;85(4):1044-1046. doi: 10.1016/j.jaad.2021.01.098. Epub 2021 Feb 3.

DOI:10.1016/j.jaad.2021.01.098
PMID:33548303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8329126/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1552/8329126/b4fef1f84b2b/nihms-1687787-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1552/8329126/b4fef1f84b2b/nihms-1687787-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1552/8329126/b4fef1f84b2b/nihms-1687787-f0001.jpg

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Topical timolol 0.5% gel-forming solution for erythema in rosacea: A quantitative, split-face, randomized, and rater-masked pilot clinical trial.0.5%噻吗洛尔凝胶形成溶液治疗酒渣鼻红斑：一项定量、半脸、随机、评估者盲法的试点临床试验。
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A randomized, controlled, split-face study of topical timolol maleate 0.5% eye drops for the treatment of erythematotelangiectatic rosacea.一项关于0.5%马来酸噻吗洛尔滴眼液治疗红斑毛细血管扩张型酒渣鼻的随机对照半脸研究。
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引用本文的文献

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Rosacea: Pathogenesis and Therapeutic Correlates.酒渣鼻：发病机制与治疗相关性。
J Cutan Med Surg. 2024 Mar-Apr;28(2):178-189. doi: 10.1177/12034754241229365. Epub 2024 Mar 7.
3
Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates.探索酒渣鼻的发病机制及机制导向治疗：既往认识与更新

本文引用的文献

1
Difference in vasoconstrictors: oxymetazoline vs. brimonidine.血管收缩剂的区别：奥塞米唑啉与溴莫尼定。
J Dermatolog Treat. 2021 Mar;32(2):137-143. doi: 10.1080/09546634.2019.1639606. Epub 2019 Aug 12.
2
Brimonidine effective but may lead to significant rebound erythema.溴莫尼定有效，但可能导致显著的反弹性红斑。
J Am Acad Dermatol. 2014 May;70(5):e109-10. doi: 10.1016/j.jaad.2014.01.853.
3
Once-daily topical brimonidine tartrate gel 0·5% is a novel treatment for moderate to severe facial erythema of rosacea: results of two multicentre, randomized and vehicle-controlled studies.
Biomedicines. 2023 Jul 31;11(8):2153. doi: 10.3390/biomedicines11082153.
每日一次局部应用酒石酸溴莫尼定凝胶 0.5%是治疗中重度酒渣鼻面部红斑的一种新方法：两项多中心、随机对照和赋形剂对照研究的结果。
Br J Dermatol. 2012 Mar;166(3):633-41. doi: 10.1111/j.1365-2133.2011.10716.x.
4
Shortterm "escape" and longterm "drift." The dissipation effects of the beta adrenergic blocking agents.短期“逃逸”和长期“漂移”。β肾上腺素能阻滞剂的消散效应。
Surv Ophthalmol. 1983 Dec;28 Suppl:235-42. doi: 10.1016/0039-6257(83)90138-8.
5
Restoring sensitivity to timolol after long-term drift in primary open-angle glaucoma.原发性开角型青光眼长期漂移后恢复对噻吗洛尔的敏感性。
Invest Ophthalmol Vis Sci. 1990 Feb;31(2):354-8.