Evidence for the neuroectodermal origin of the human lacrimal gland.

Immunohistochemical staining with antineuronal-specific enolase antibodies showed a positive reaction product in the acini and in the nerves of human major and accessory lacrimal glands. The fibrous tissue interstitium, septae, capsule, and blood vessels reacted negatively. Our findings indicate that the acinar portion of the lacrimal gland, but not the fibrous tissue component, is derived from neuroectoderm. We propose that the acini of the human lacrimal glands develop, not as an ingrowth into the mesenchymal stroma from the surface ectoderm that forms the conjunctiva, but as an outgrowth from the embryonic neuroectoderm, and more specifically, from cells that have migrated from the neural crest.