Department of Chemical Engineering, Sahand University of Technology, PO Box 51335-1996, Tabriz, Iran.
Mol Biotechnol. 2013 Nov;55(3):288-97. doi: 10.1007/s12033-013-9700-6.
Small non-coding RNAs (sRNAs) play a significant role in regulation of bacterial physiological behaviors. After sensing any environmental cue such as fluctuation of nutrient concentration, temperature, pH, and osmolarity, these sRNAs interfere to transmit these signals to target regulators and genes. sRNAs have key role in biofilm formation process by base pairing with target mRNAs or interaction with modulating proteins to both positive and negative regulation mechanisms. There are various regulatory systems to characterize the initiation and formation of special bacterial biofilms that are mostly described as two component systems based on sRNAs functions. In this study, regulatory pathways that are important for biofilm formation and genetic responses to environmental stimuli in mature biofilms were evaluated. Some of the regulatory systems that produce common types of biofilms such as curli, PGA, cellulose and polysaccharides such as alginate, colonic acid, Psl and their involved sRNAs functions were also discussed.
小非编码 RNA（sRNAs）在调节细菌生理行为方面发挥着重要作用。在感知到任何环境信号（如营养浓度、温度、pH 值和渗透压的波动）后，这些 sRNAs 会干扰并将这些信号传递给靶标调节剂和基因。sRNAs 通过与靶 mRNA 碱基配对或与调节蛋白相互作用，在生物膜形成过程中发挥关键作用，从而对正向和负向调控机制进行调控。有多种调节系统来描述特殊细菌生物膜的起始和形成，这些系统大多基于 sRNAs 的功能描述为双组分系统。在这项研究中，评估了对成熟生物膜中生物膜形成和遗传对环境刺激反应的重要调节途径。还讨论了产生常见类型生物膜（如卷曲菌、PGA、纤维素和多糖（如藻酸盐、粘酸、Psl）的调节系统及其涉及的 sRNAs 功能。
