Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India; Departments of Child Health Units I, II and III, Christian Medical College, Vellore, India.
Am J Trop Med Hyg. 2013 Nov;89(5):1019-22. doi: 10.4269/ajtmh.13-0121. Epub 2013 Sep 23.
The distribution of norovirus (NoV) genogroup II in children < 5 years of age admitted to a south Indian hospital with diarrhea was investigated. Viral RNA extracted from 282 stool samples were screened for NoV GII and positive amplicons sequenced. Twenty-eight (9.9%) had NoV GII infection with a median age of 6 months, with more severe episodes of diarrhea among infected (median Vesikari score 13, interquartile range [IQR] 10-15) than children without infection (median score 10, IQR 8-13, P = 0.002). The study documents NoV GII infections as an important cause of gastroenteritis and the genetic diversity of circulating strains.
研究调查了在印度南部一家医院因腹泻住院的 5 岁以下儿童中诺如病毒（NoV）基因 II 组的分布情况。从 282 份粪便样本中提取病毒 RNA，对 NoV GII 进行筛查，并对阳性扩增子进行测序。28 例（9.9%）存在 NoV GII 感染，中位年龄为 6 个月，感染组的腹泻症状更严重（Vesikari 评分中位数为 13，四分位距[IQR]为 10-15），而非感染组（评分中位数为 10，IQR 为 8-13，P = 0.002）。该研究证明了 NoV GII 感染是导致胃肠炎的一个重要原因，以及循环毒株的遗传多样性。
