Division of Virology, National Institute of Cholera and Enteric Diseases, P-33 C.I.T Road, Scheme XM, Beliaghata, Kolkata, West Bengal, India.
Epidemiol Infect. 2011 Jun;139(6):910-8. doi: 10.1017/S0950268810001731. Epub 2010 Jul 19.
Faecal specimens of diarrhoea cases (n=2495, collected between November 2007 and October 2009) from Infectious Diseases and Beliaghata General (ID&BG) Hospital, Kolkata, India, were screened by RT-PCR using specific primers targeting region C of the capsid gene of noroviruses (NoVs) to determine the seasonal distribution and clinical characteristics of NoVs associated with diarrhoea. NoV infection was detected in 78 cases, mostly in children aged <2 years. In 22/78 positive cases, the virus was detected as the sole agent; others were as mixed infections with other enteric pathogens. Sequencing of NVGII strains showed clustering with GII.4 NoVs followed by GII.13 and GII.6 NoVs. Clinical characteristics of the diarrhoeic children and adults in Kolkata indicated that NoV infections were detected throughout the year and were associated with a mild degree of dehydration.
从印度加尔各答传染病和贝利加塔综合医院（ID&BG）采集的腹泻病例粪便标本（2007 年 11 月至 2009 年 10 月采集，n=2495），通过 RT-PCR 用针对诺如病毒（NoV）衣壳基因区 C 的特异性引物进行筛查，以确定与腹泻相关的 NoV 的季节性分布和临床特征。在 78 例中检测到 NoV 感染，主要发生在年龄<2 岁的儿童中。在 22/78 例阳性病例中，该病毒被检测为单一病原体；其他则为与其他肠道病原体的混合感染。对 NVGII 株的测序显示与 GII.4 NoV 聚集，其次是 GII.13 和 GII.6 NoV。加尔各答腹泻儿童和成人的临床特征表明，NoV 感染全年均可检测到，并与轻度脱水有关。
