The TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA.
Eur Heart J Acute Cardiovasc Care. 2012 Apr;1(1):9-12. doi: 10.1177/2048872612438026.
Since Herrick's description of the clinical picture of acute myocardial infarction exactly one century ago (1912), there have been three phases of therapy: Phase 1 (1912-1961, bed rest and 'expectant' treatment); Phase 2 (1961-1974, the coronary care unit); and Phase 3 (1975-present, myocardial reperfusion). We are now on the cusp of Phase 4, which comprises efforts to reduce myocardial perfusion injury as well as regenerative medicine.
自 100 年前（1912 年） Herrick 描述急性心肌梗死的临床特征以来，治疗经历了三个阶段：第一阶段（1912-1961，卧床休息和“期待”治疗）；第二阶段（1961-1974，冠心病监护病房）；以及第三阶段（1975 年至今，心肌再灌注）。我们现在正处于第四阶段的边缘，这一阶段包括努力减少心肌灌注损伤和再生医学。
