Liu Yue, Zhang Jing-Chun, Shi Da-Zhuo, Chen Ke-Ji
Center for Cardiovascular Disease, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Jul;33(7):869-72.
In recent years a huge amount of clinical studies have proved that fluctuant hypertension could aggravate the damage of target organs and increase the incidence of acute cardio-/cerebrovascular events, when compared with stable hypertension [increased mean artery blood pressure (MBP)]. How to prevent and treat fluctuant hypertension and its damage of target organs has become one of the hot and difficult problems in the field of hypertension studies all over the world. Hypertensive patients often suffer from thromboembolic target organ damage. Platelet activation plays a key role in this progress, but its concrete mechanisms have not been clearly clarified. Based on the in-depth discussions on progress of fluctuant hypertension, its relationship with platelet activation and blood stasis syndrome of Chinese medicine (CM) in recent three years, we proposed, under the fluctuant hypertensive state, the prethrombotic state has occurred in the organisms, i.e., a pathological state featured by platelet activation, liable to have vulnerable thrombopoiesis, and accompanied by endothelial dysfunction. Blood stasis syndrome might occupy an important position in CM syndrome typing of fluctuant hypertension. Herbs for activating blood circulation and removing stasis might have an extensive application prospect.
近年来大量临床研究证明，与稳定高血压（平均动脉血压升高）相比，波动性高血压会加重靶器官损害并增加急性心脑血管事件的发生率。如何防治波动性高血压及其靶器官损害已成为全球高血压研究领域的热点和难点问题之一。高血压患者常伴有血栓栓塞性靶器官损害。血小板活化在这一过程中起关键作用，但其具体机制尚未完全阐明。基于近三年对波动性高血压进展、其与血小板活化及中医血瘀证关系的深入探讨，我们提出，在波动性高血压状态下，机体已出现血栓前状态，即一种以血小板活化为特征、易于形成易损性血栓形成且伴有内皮功能障碍的病理状态。血瘀证可能在波动性高血压的中医证候分型中占据重要地位。活血化瘀中药可能具有广阔的应用前景。
