Chen Zhuo, Wang Liqiong, Yang Guoyan, Xu Hao, Liu Jianping
Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China.
Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Evid Based Complement Alternat Med. 2015;2015:582751. doi: 10.1155/2015/582751. Epub 2015 May 18.
Objective. The aim of this systematic review is to evaluate effect of Chinese medicine combined with conventional therapy on blood pressure variability (BPV) in hypertension patients. Methods. All randomized clinical trials (RCTs) comparing Chinese medicine with no intervention or placebo on the basis of conventional therapy were included. Data extraction, analyses, and quality assessment were performed according to the Cochrane standards. Results. We included 13 RCTs and assessed risk of bias for all the trials. Chinese medicine has a significant effect in lowering blood pressure (BP), reducing BPV in the form of standard deviation (SD) or coefficient of variability (CV), improving nighttime BP decreased rate, and reversing abnormal rhythm of BP. Conclusions. Chinese medicine was safe and showed beneficial effects on BPV in hypertension patients. However, more rigorous trials with high quality are warranted to give high level of evidence before recommending Chinese medicine as an alternative or complementary medicine to improve BPV in hypertension patients.
目的。本系统评价旨在评估中药联合传统疗法对高血压患者血压变异性（BPV）的影响。方法。纳入所有在传统疗法基础上比较中药与无干预或安慰剂的随机临床试验（RCT）。根据Cochrane标准进行数据提取、分析和质量评估。结果。我们纳入了13项RCT，并评估了所有试验的偏倚风险。中药在降低血压（BP）、以标准差（SD）或变异系数（CV）形式降低BPV、提高夜间血压下降率以及逆转异常血压节律方面具有显著效果。结论。中药对高血压患者的BPV安全且显示出有益作用。然而，在推荐中药作为改善高血压患者BPV的替代或补充药物之前，需要进行更严格的高质量试验以提供高水平证据。
