Department of Animal Sciences, NDSU 7630, P.O. Box 6050, Fargo, ND 58103-6050, USA.
Curr Vasc Pharmacol. 2013 Sep;11(5):564-93. doi: 10.2174/1570161111311050003.
This review discusses the importance of placental vascular development, as reflected by placental angiogenesis and placental blood flow, to placental function in normal pregnancies. We then summarize our current understanding of how maternal stress, including inadequate maternal nutrition as well as the application of assisted reproductive technologies (ART), leads to compromised placental angiogenesis and function and the subsequent effects on fetal and neonatal growth and development. Finally, we discuss several promising therapeutic approaches to 'rescue' placental vascular development and function in compromised pregnancies, leading to improved pregnancy and postnatal outcomes.
本篇综述讨论了胎盘血管发育（表现为胎盘血管生成和胎盘血流）对正常妊娠中胎盘功能的重要性。然后，我们总结了目前对于母体应激（包括母体营养不足以及辅助生殖技术的应用）如何导致胎盘血管生成和功能受损，以及对胎儿和新生儿生长发育的后续影响的理解。最后，我们讨论了几种有前途的治疗方法，以“挽救”有问题妊娠中的胎盘血管发育和功能，从而改善妊娠和产后结局。
