Groupe Immunité des Muqueuses et Agents Pathogènes (GIMAP) - EA3064, Faculty of Medicine of Saint-Etienne, 42023, University of Lyon, France.
Expert Rev Mol Diagn. 2013 Sep;13(7):693-705. doi: 10.1586/14737159.2013.829703.
Nuclear acid testing is more and more used for the diagnosis of infectious diseases. This paper focuses on the use of molecular tools for HIV screening. The term 'screening' will be used under the meaning of first-line HIV molecular techniques performed on a routine basis, which excludes HIV molecular tests designed to confirm or infirm a newly discovered HIV-seropositive patient or other molecular tests performed for the follow-up of HIV-infected patients. The following items are developed successively: i) presentation of the variety of molecular tools used for molecular HIV screening, ii) use of HIV molecular tools for the screening of blood products, iii) use of HIV molecular tools for the screening of organs and tissue from human origin, iv) use of HIV molecular tools in medically assisted procreation and v) use of HIV molecular tools in neonates from HIV-infected mothers.
核酸检测在传染病诊断中的应用越来越广泛。本文重点介绍了分子工具在 HIV 筛查中的应用。本文中“筛查”一词的含义是指在常规基础上进行的一线 HIV 分子检测技术，不包括旨在确认或否定新发现的 HIV 血清阳性患者的 HIV 分子检测，也不包括为 HIV 感染者随访而进行的其他分子检测。以下内容依次为：i）用于分子 HIV 筛查的分子工具的多样性介绍，ii）血液制品的 HIV 分子筛查工具的使用，iii）人体器官和组织的 HIV 分子筛查工具的使用，iv）在辅助生殖中的 HIV 分子筛查工具的使用，以及 v）HIV 感染母亲的新生儿中的 HIV 分子筛查工具的使用。
