Yong Loo Lin School of Medicine, National University of Singapore , Singapore .
Ocul Immunol Inflamm. 2014 Feb;22(1):9-14. doi: 10.3109/09273948.2013.829106. Epub 2013 Sep 24.
To report the presentations of syphilitic uveitides in Singapore.
Retrospective noncomparative observational case series of 18 eyes from 12 patients with ocular syphilis between 2004 and 2009.
Patients were mainly male (91.7%). Median age was 49.5 (24-84) years. Initial visual acuity varied from 6/6 to counting fingers (CF) and was ≥6/12 in 7 eyes (38.8%). Blurring of vision (n = 11, 61.1%) was the most common presenting complaint. Anterior uveitis and panuveitis were both most common (n = 6, 33.3%). Treponemal and nontreponemal serologies were positive in 12 (100.0%) and 10 (83.3%) patients, respectively. Patients were treated systematically with penicillin therapy by infectious disease physicians.
Ocular syphilis is seeing a worldwide resurgence. Although anterior uveitis and panuveitis were most common in this study, there was a large spectrum of ocular manifestations. Syphilitic uveitides can potentially cause severe loss of vision but are effectively treated by an appropriate regimen of penicillin.
报告新加坡梅毒性葡萄膜炎的表现。
对 2004 年至 2009 年间 12 例眼部梅毒患者的 18 只眼进行回顾性非对照观察性病例系列研究。
患者主要为男性（91.7%）。中位年龄为 49.5（24-84）岁。初始视力从 6/6 到指数（CF）不等，7 只眼（38.8%）≥6/12。视力模糊（n=11，61.1%）是最常见的主诉。前葡萄膜炎和全葡萄膜炎均最常见（n=6，33.3%）。12 例（100.0%）和 10 例（83.3%）患者的梅毒螺旋体和非梅毒螺旋体血清学均为阳性。患者均由传染病医生进行系统的青霉素治疗。
眼部梅毒正在全球范围内重新出现。尽管本研究中最常见的是前葡萄膜炎和全葡萄膜炎，但仍存在广泛的眼部表现。梅毒性葡萄膜炎可能导致严重视力丧失，但适当的青霉素治疗方案可有效治疗。
