Instituto de Química Orgánica General, IQOG-CSIC , Juan de la Cierva 3, 28006 Madrid, Spain, and Instituto de Química Física Rocasolano, IQFR-CSIC , Serrano 119, 28006 Madrid, Spain.
Org Lett. 2013 Oct 4;15(19):4936-9. doi: 10.1021/ol402141d. Epub 2013 Sep 24.
The highly selective base-promoted cyclization of enantiopure sulfinyl dienamines provides stereodefined sulfinyl 1,2,3,6-tetrahydropyridines (dr up to 99:1). Subsequent sigmatropic rearrangement affords tetrahydropyridin-3-ols in good yields and selectivities.
手性磺亚胺二烯胺经高立体选择性的基底促进环化反应，可得到立体定义明确的磺酰基 1,2,3,6-四氢吡啶（dr 高达 99:1）。随后的[3,3]-σ重排以良好的收率和选择性得到四氢吡啶-3-醇。
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