急性视网膜坏死患者抗病毒治疗的全身副作用
Systemic side effects of antiviral therapy in a patient with acute retinal necrosis.
作者信息
Guney Esra, Akcay Betul Ilkay Sezgin, Erdogan Gurkan, Unlu Cıhan, Bozkurt Kansu, Onur Umut
机构信息
Department of Ophthalmology, Umraniye Training and Research Hospital , Istanbul , Turkey and.
出版信息
Ocul Immunol Inflamm. 2014 Jun;22(3):233-5. doi: 10.3109/09273948.2013.833632. Epub 2013 Sep 24.
PURPOSE
To report a case of Acute Retinal Necrosis (ARN)-developed nephrotoxicity during intravenous acyclovir treatment and toxic hepatitis during oral valacyclovir treatment.
DESIGN
Interventional case report.
METHODS
Retrospective chart review.
RESULTS
A 45-year-old male with ARN treated with intravenous acyclovir developed nephrotoxicity. After switching to oral valacyclovir, toxic hepatitis developed. Both renal and liver function tests returned to normal levels after drug cessation
CONCLUSIONS
Although rare, clinicians should be aware of the potential nephrotoxic and hepatotoxic side effects of antiviral therapy during ARN treatment.
目的
报告1例急性视网膜坏死（ARN）患者在静脉注射阿昔洛韦治疗期间出现肾毒性，以及在口服伐昔洛韦治疗期间出现药物性肝炎的病例。
设计
介入性病例报告。
方法
回顾性病历审查。
结果
1例45岁男性ARN患者在接受静脉注射阿昔洛韦治疗时出现肾毒性。改用口服伐昔洛韦后，出现药物性肝炎。停药后肾功能和肝功能检查均恢复至正常水平。
结论
尽管罕见，但临床医生在ARN治疗期间应意识到抗病毒治疗可能存在的肾毒性和肝毒性副作用。
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